1P-LSD 100 MCG Blotters

Buy 1P-LSD 100 MCG Blotters Research Chemical Online – USA, Europe & Worldwide

RChems EU is proud to offer 1P-LSD 100 MCG Blotters, a foundational research chemical format for academic and industrial laboratories investigating the pharmacology of acylated lysergamides. 1P-LSD (1-Propionyl-d-lysergic acid diethylamide) is a semi-synthetic ergoline derivative that has become a reference standard for studying the impact of 1-acyl substitution on serotonin 5-HT2A receptor binding, functional activity, and metabolic stability. Unlike the freebase powder—which requires precise microbalance weighing—our blotter format provides pre-dosed, perforated squares each containing exactly 100 micrograms of ≥99% pure 1P-LSD. This allows researchers to rapidly prepare stock solutions of known concentration by extracting a defined number of blotters in methanol, ethanol, or DMSO, eliminating weighing errors and reducing inter-researcher variability. The 100 mcg dosage is specifically calibrated for equimolar comparison studies with LSD (which is typically studied at 100 mcg per dose in reference literature) and other 1-acylated analogues. Whether you need to buy 1P-LSD 100 MCG blotters for receptor binding assays, functional GPCR studies, metabolic stability experiments, or analytical reference method development, RChems EU delivers uncompromising quality. As a trusted global supplier, we ensure every order arrives via fast worldwide delivery in discreet, unmarked packaging with no external chemical identifiers.

Key Features & Benefits

• 99% Purity Guaranteed: Bulk 1P-LSD powder validated by HPLC-DAD, ¹H/¹³C NMR, and HRMS before blotter dosing.
• Precision-Dosed Blotters: Each ¼ inch square contains exactly 100 mcg ±2% – no weighing, no volumetric dilution errors.
• Perforated Format: Easy subdivision for multiple assays; simply tear along perforations.
• Research-Ready Extraction: Blotters can be directly extracted into organic solvents for stock solution preparation.
• Discreet Global Shipping: Plain outer packaging, vacuum-sealed inner pouch, no chemical names on parcel.
• Batch Homogeneity Testing: Random sampling ensures consistent dosage across each sheet.
• Classic Research Format: The 100 mcg dosage aligns with historical lysergamide research literature.

Product Specifications

Property	Specification
IUPAC Name	(6aR,9R)-N,N-diethyl-7-methyl-1-propionyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
Purity (Bulk Powder HPLC)	≥99% (area under curve, 254 nm)
Dosage per Blotter	100 mcg (micrograms) ±2% RSD
Blotter Size	6×6 mm (¼ inch) perforated squares
Blotter Material	High-quality, acid-free, lignin-free blotter paper
Appearance	Neutral or minimally patterned paper (no artistic branding that could be misconstrued)
Solubility (Freebase)	>10 mg/mL in ethanol, >25 mg/mL in DMSO
log P (calculated)	2.9 (freebase)
Storage Conditions	Cool (15–25°C), dry, airtight, protected from light

Applications & Usage

1P-LSD 100 MCG Blotters are intended exclusively for legitimate scientific research. Typical applications include:

• Receptor Binding Affinity Studies: Quantifying 1P-LSD’s binding affinity (Ki) at human serotonin receptors (5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT7) using radioligand displacement assays (e.g., [³H]-LSD, [³H]-ketanserin). Extract 1–10 blotters in methanol to create accurate stock solutions. Compare across the 1-acyl lysergamide series (1P-LSD, 1cP-LSD, 1B-LSD, 1V-LSD) to map acyl chain length effects.
• Functional GPCR Assays: Measuring Gαq-mediated IP3 accumulation, calcium flux (Fluo-4, Fura-2), or β-arrestin recruitment in transfected cell lines (HEK-293 or CHO-K1 expressing recombinant human 5-HT2A receptors). The 100 mcg dosage allows rapid preparation of concentration-response curves.
• Metabolic Stability Studies: Investigating phase I deacylation rates using human liver microsomes (HLM), recombinant CYP enzymes (CYP3A4, CYP2D6, CYP1A2), or primary human hepatocytes. Quantify the rate of 1P-LSD conversion to LSD via LC-MS/MS.
• Structure-Activity Relationship (SAR) Research: Systematically comparing 1-acyl chain length (C2, C3, C4, C5) to understand how acyl group lipophilicity and steric bulk affect receptor binding, functional activity, and metabolic stability. 1P-LSD (propionyl, C3) serves as the reference point.
• Analytical Reference Standard: Use extracted blotters as a certified reference material for LC-MS/MS or LC-QTOF method development in forensic toxicology for the detection of 1P-LSD and its LSD metabolite in research matrices.
• Prodrug Activation Studies: Investigating the enzymatic and non-enzymatic hydrolysis of the 1-propionyl group under simulated physiological conditions (pH 7.4, 37°C) to determine half-life and activation kinetics.

When researchers buy 1P-LSD blotters for research, the 100 mcg pre-dosed format is particularly advantageous for laboratories that lack microbalances or that process large numbers of samples. Simply extract one blotter per 1 mL of methanol to produce a 100 mcg/mL (0.1 mg/mL) stock solution—no weighing, no calculation errors. This ensures reproducible, publication-grade results across multiple experimental replicates.

Purity & Testing

At RChems EU, our quality assurance protocol for 1P-LSD 100 MCG Blotters involves a two-stage testing approach: bulk powder characterization followed by blotter homogeneity verification.

Stage 1: Bulk Powder Testing (before blotter dosing)

1. High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD): Quantifies bulk purity at ≥99% across three UV wavelengths (220 nm, 254 nm, 310 nm). Detects related substances including iso-1P-LSD, lysergic acid, 1-propionyl-lysergic acid, and unreacted intermediates—each below 0.5% if present.
2. Nuclear Magnetic Resonance Spectroscopy (¹H NMR and ¹³C NMR, 400 MHz): Confirms the expected proton and carbon environments for 1P-LSD freebase. Validates the integrity of the propionyl group (characteristic triplet and quartet signals). Rules out residual solvents above ICH Q3C limits.
3. High-Resolution Mass Spectrometry (HRMS-ESI): Confirms the exact mass of the [M+H]⁺ ion at m/z 380.2333 (calculated for C₂₃H₃₀N₃O₂). Detects trace impurities with mass accuracy <3 ppm.
4. Karl Fischer Titration: Ensures residual water content <1%, confirming powder stability.

Stage 2: Blotter Homogeneity Testing (after dosing)

1. Random Sampling Extraction (HPLC-UV): Ten randomly selected blotters per sheet are individually extracted into methanol and analyzed by HPLC-UV (310 nm). Acceptance criterion: each blotter contains 100 mcg ±2% RSD (i.e., 98–102 mcg). Batch is rejected if any blotter falls outside 95–105 mcg or if relative standard deviation exceeds 3%.

When you buy 99% pure 1P-LSD 100 MCG blotters from RChems EU, each batch is accompanied by a Certificate of Analysis (COA) summarizing all five test results, including homogeneity data. This transparency ensures that your research findings are not confounded by dosage variability—a critical advantage for quantitative receptor assays and metabolic studies.

Safety & Handling Guidelines

FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

• Personal Protective Equipment (PPE): Wear nitrile gloves and safety goggles when handling blotters. Change gloves between handling different batches to avoid cross-contamination.
• Engineering Controls: Perform blotter extractions in a certified chemical fume hood to avoid aerosolization during vortexing or sonication.
• Handling: Use clean forceps (not fingers) to handle individual blotters. Do not tear blotters with bare hands.
• Surface Decontamination: Clean spills immediately with 10% bleach solution followed by 70% ethanol. Absorb with damp paper towel and dispose as hazardous waste.
• Storage: Store blotters in the original vacuum-sealed foil pouch at cool room temperature (15–25°C) in a dry, dark place. Do not refrigerate unsealed blotters. Keep desiccant in the outer container.
• Disposal: Follow institutional hazardous waste protocols for controlled substance analogues. Do not dispose in sink drains or general trash.

Global Shipping & Discreet Delivery

RChems EU understands that confidentiality and reliability are paramount when ordering research chemicals. As emphasized across our product catalog, all orders are handled with confidentiality and shipped in discreet packaging to protect your privacy. Every order of 1P-LSD 100 MCG Blotters is shipped using our proprietary StealthShield™ protocol:

• Plain Outer Packaging: No logos, no branding, no mention of “RChems EU” on the exterior. Return address uses a neutral logistics partner name.
• Unmarked Labels: Customs declarations read “Laboratory blotter samples for analysis” or “Inert research materials”—never “1P-LSD,” “LSD analogue,” or “research chemical.”
• Vacuum-Sealed Inner Pouch: Blotters are placed between acid-free cardboard inserts and heat-sealed inside an opaque, multi-layer foil vacuum pouch to prevent moisture ingress, eliminate any odor, provide tamper evidence, and obscure X-ray identification.
• Desiccant Included: A silica gel packet is placed inside the vacuum pouch to maintain low humidity.
• Fast Worldwide Delivery (Typical transit times):
  • USA: 4–7 business days
  • Canada: 5–8 business days
  • United Kingdom: 4–6 business days
  • European Union: 5–9 business days
  • Australia & New Zealand: 6–11 business days
  • Rest of world: 7–14 business days
• Discrete Tracking: Tracking number provided via email with no product details on the tracking portal.

Whether you require 1P-LSD 100 MCG blotters discreet shipping to a university neuroscience laboratory, a contract research organization, or a private research facility, RChems EU guarantees that no third party will identify the contents.

Why Choose RChems EU?

• Trusted Global Supplier: Thousands of shipments to 50+ countries with a 99.5% delivery success rate.
• Stealth Packaging Pioneer: Over 5 years of refinement in discretion methods. All orders are handled with confidentiality and shipped in discreet packaging.
• Precision Blotter Format: Eliminates weighing errors and reduces inter-researcher variability.
• Fast Logistics Network: Pre-cleared routing through EU and US hubs reduces customs holds.
• Responsive Scientific Support: Encrypted email and live chat available 6 days per week.
• Batch Traceability: Every batch linked to unique lot number with downloadable COA including homogeneity data.
• Flexible Quantities: Multiple sheet quantities available for studies of any scale.

Legal & Safety Disclaimer

By purchasing 1P-LSD 100 MCG Blotters from RChems EU, you acknowledge and agree:

• The product is intended strictly for in vitro research, forensic analysis, and legitimate scientific investigation—not for human or veterinary use, not for consumption, and not for any form of self-administration. While 1P-LSD is known to induce psychedelic effects in published literature, these properties are only relevant to controlled, approved research—not to consumer use.
• You are at least 18 years of age and possess any required institutional or governmental authorizations.
• You are solely responsible for compliance with all local, state, national, and international laws. 1P-LSD is unscheduled in many jurisdictions but may be considered a controlled substance analogue where analogue laws exist.
• RChems EU reserves the right to cancel orders from regions where lysergamides or their analogues are explicitly prohibited (e.g., Australia, Sweden, Norway, Germany under NpSG).
• No medical, therapeutic, or psychoactive claims are made or implied. This product is not a drug or dietary supplement.
• Blotters are for laboratory use only; the paper substrate is not intended to facilitate any form of administration outside of validated research protocols.

FAQ Section

1. What is 1P-LSD used for in research?

1P-LSD (1-Propionyl-d-lysergic acid diethylamide) is an acylated lysergamide analogue used to study serotonin 5-HT2A receptor pharmacology, prodrug activation kinetics, and structure-activity relationships. Researchers employ 1P-LSD 100 MCG Blotters in receptor binding assays (determining Ki values), functional GPCR studies (calcium flux, IP3 accumulation, β-arrestin recruitment), metabolic stability assays (quantifying deacylation rates to LSD using human liver microsomes), and as an analytical reference standard. The 100 mcg pre-dosed blotter format aligns with historical LSD research literature for equimolar comparisons. It is strictly a research tool—not for human or veterinary use.

2. Is 1P-LSD legal to buy online?

The legal status of 1P-LSD for research varies significantly by jurisdiction. In the United States, 1P-LSD is not explicitly listed in the Controlled Substances Act schedules, but the Federal Analogue Act may apply if intent for human consumption is demonstrated. In the European Union, laws differ—some countries regulate lysergamides under generic analogue legislation (e.g., Germany’s NpSG), while others have no specific scheduling. Some countries (e.g., Australia, Sweden, Norway) have explicitly banned 1P-LSD. RChems EU sells 1P-LSD 100 MCG blotters strictly as a research chemical. Buyers are solely responsible for verifying local laws before ordering. We do not ship to Australia, Sweden, Norway, or other jurisdictions where lysergamide analogues are explicitly banned.

3. How discreet is your shipping for 1P-LSD 100 MCG blotters?

Extremely discreet. All orders are handled with confidentiality and shipped in discreet packaging to protect your privacy. Your 1P-LSD 100 MCG blotters order arrives in plain, unbranded outer packaging with no company logo, no chemical name, and no mention of “research chemical” anywhere on the exterior. The return address uses a generic logistics name. Customs declarations use vague descriptions such as “Laboratory blotter samples for analysis” or “Inert research materials.” Inside, blotters are vacuum-sealed inside an opaque, multi-layer foil pouch. No third party—postal workers, customs officers, or neighbors—will identify the contents. This ensures complete confidentiality for academic and industrial researchers.

4. What is the purity level of your 1P-LSD 100 MCG blotters?

Our 1P-LSD 100 MCG blotters are manufactured from bulk 1P-LSD powder that tests at ≥99% purity by HPLC-DAD (three wavelengths). The remaining <1% comprises trace residual solvents (<0.3% each) and water (<1%). No undeclared adulterants, cutting agents, or isomeric impurities are present. After dosing onto blotters, we perform random homogeneity testing to confirm each 100 mcg blotter is within ±2% of the target dose (98–102 mcg). The blotter paper itself is high-purity, acid-free, and lignin-free—it does not introduce contaminants.

5. How do you test the dosage accuracy of each 100 mcg blotter?

We perform a two-stage testing process. First, the bulk 1P-LSD powder is tested by HPLC-DAD, NMR, and HRMS for ≥99% purity. Second, after dosing, we randomly select ten blotters per sheet, individually extract them into methanol, and analyze by HPLC-UV (310 nm). The acceptance criterion is 100 mcg ±2% RSD (i.e., 98–102 mcg per blotter). The batch is rejected if any blotter falls outside 95–105 mcg or if the relative standard deviation exceeds 3%. A Certificate of Analysis with homogeneity data is available by batch number.

6. Can I track my 1P-LSD blotters shipment internationally?

Yes. All orders receive a discrete tracking number via encrypted email within 24–48 hours of dispatch. You can monitor progress from our warehouse through your local delivery hub (USPS, Royal Mail, DHL, Deutsche Post, etc.). The tracking portal displays only “Shipment in transit” and estimated delivery dates—no product details, no chemical names, no reference to RChems EU or “research chemical.” We offer worldwide shipping to accommodate researchers from various locations. For maximum privacy, use an institutional address or a trusted commercial receiving point.

7. How should I store 1P-LSD 100 MCG blotters?

Store 1P-LSD 100 MCG blotters in the original vacuum-sealed foil pouch at cool room temperature (15–25°C / 59–77°F) in a dry, dark place (e.g., a drawer or cabinet away from heat sources and direct sunlight). Do not refrigerate the pouch unless it remains unopened; condensation upon opening a cold pouch can degrade blotters. Keep desiccant in the outer container. Under these conditions, the blotters remain stable (≥98% of initial potency) for at least 12 months. For longer-term archival (>1 year), store the unopened vacuum pouch in a refrigerator (2–8°C) and allow to warm to room temperature for 2 hours before opening to prevent condensation.

8. Why choose the 100 mcg dosage for 1P-LSD research?

The 100 mcg dosage on these blotters is specifically calibrated for equimolar comparison with LSD reference literature. LSD is historically studied at 100 mcg doses in receptor binding and functional assays. Because 1P-LSD has a higher molecular weight (379.50 g/mol vs. LSD’s 323.43 g/mol), a 100 mcg blotter of 1P-LSD contains approximately 20% fewer molecules than a 100 mcg blotter of LSD. However, for prodrug studies where 1P-LSD is expected to deacylate to LSD, the 100 mcg dosage provides a convenient starting point for metabolic assays. Researchers performing direct comparative studies should calculate equimolar corrections; our 100 mcg blotters are labeled with mass (not molarity) to allow researchers to make their own adjustments.

9. How do I prepare a stock solution from 1P-LSD blotters?

For in vitro applications (receptor binding assays, cell culture studies, enzyme assays): Place one blotter in a glass vial, add 1 mL of methanol or ethanol, and vortex for 2–3 minutes. Allow to extract for 30 minutes at room temperature with occasional agitation. Centrifuge or filter (0.22 µm PTFE) to remove paper fibers. The resulting stock solution contains approximately 100 mcg/mL (0.1 mg/mL) of 1P-LSD. For aqueous buffers (PBS, HEPES), dilute the organic stock solution such that the final organic solvent concentration is ≤1% (v/v) to avoid cellular toxicity. Always include vehicle controls. For quantitative recovery, multiple sequential extractions may be performed; typical single-extraction recovery is >95%.

10. Do you offer 1P-LSD in other formats (pellets, powder)?

Yes. While the 1P-LSD 100 MCG Blotter format is optimized for researchers familiar with traditional lysergamide research methods, RChems EU also supplies 1P-LSD as pre-dosed 150 MCG pellets (for solid dosage studies requiring greater stability) and as 99% pure crystalline L-tartrate powder (for laboratories that require precise weight-based dosing for quantitative extraction efficiency studies or analytical method development). Please see our product catalog for these alternative formats. All formats undergo the same rigorous analytical testing and are shipped with the same discreet packaging protocols.

Advance your lysergamide research with blotter precision and uncompromising quality. Order 1P-LSD 100 MCG Blotters from RChems EU today and experience the global standard in 99% purity, verified dose homogeneity, proven discreet worldwide delivery, and full analytical transparency. Buy 1P-LSD 100 MCG blotters online with confidence—only from RChems EU.