4C-MAR (4-Chlorine-4-methylaminorex)

Buy 4C-MAR Research Chemical Online – USA, Europe & Worldwide

The aminorex class of research chemicals has become increasingly significant in neuropharmacology due to their potent monoamine-releasing properties. 4C-MAR (4-Chlorine-4-methylaminorex) , also referred to as 4-Chloro-4-methylaminorex, is a structural analog of the parent compound 4-methylaminorex, distinguished by the introduction of a chlorine atom at the 4-position of the phenyl ring. This halogen substitution fundamentally alters the compound’s electronic properties, lipophilicity, and steric profile, making it a critical tool for structure-activity relationship (SAR) studies examining the effects of halogen variation on monoamine transporter activity.

Chlorine substitution occupies an intermediate position in the halogen series (F, Cl, Br), offering a balance between electronegativity, size, and lipophilicity. For researchers investigating the molecular mechanisms of monoamine releasing agents and the impact of halogen selection on dopamine, norepinephrine, and serotonin transporter interactions, 4C-MAR provides a distinct chemical probe alongside its fluorinated (4F-MAR) and brominated (4B-MAR) analogs. When you buy 4C-MAR from RChems EU, you acquire a high-purity research compound manufactured under strict quality controls. Our 99% pure 4C-MAR is intended exclusively for laboratory research—not for human or animal consumption—enabling precise, reproducible experiments in receptor pharmacology, neurochemistry, and behavioral neuroscience.

Key Features & Benefits

• Verified 99%+ Purity: Every batch undergoes independent HPLC, LC-MS, and ¹H/¹³C NMR analysis to guarantee ≥99% purity.
• Chlorinated Aminorex Analog: The 4-chloro substitution enables SAR studies comparing halogen effects (F, Cl, Br) on monoamine transporter activity.
• Potent Monoamine Releasing Agent: Investigates dopamine (DAT), norepinephrine (NET), and serotonin (SERT) transporter interactions in in vitro models.
• Aminorex Class Research Tool: Structurally related to 4-methylaminorex for comparative pharmacology studies across halogenated derivatives.
• Intermediate Halogen Properties: Chlorine offers a balance between fluorine (small, electronegative) and bromine (larger, more polarizable), ideal for systematic SAR investigations.
• Distinct Pharmacokinetic Profile: Chlorine substitution alters metabolic stability compared to non-halogenated and other halogenated analogs.
• Worldwide Delivery: Fast, tracked shipping to the USA, Canada, Europe, Australia, and select Asian research hubs.
• Discreet Packaging Protocol: Plain outer boxes, unmarked labels, vacuum-sealed inner bags—no chemical names on the parcel.

Product Specifications

Applications & Usage

⚠️ Strictly for laboratory research use only. Not for human or animal consumption.

4C-MAR is utilized in a range of non-clinical, pre-clinical, and basic science research applications. Typical areas of investigation include:

• Monoamine Transporter Binding Assays: Evaluating affinity (Ki) for dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT) using radioligand displacement (e.g., [³H]WIN 35,428 for DAT, [³H]nisoxetine for NET, [³H]citalopram for SERT) in transfected cell lines or synaptosomal preparations.
• Neurotransmitter Release Assays: Measuring monoamine release using in vitro superfusion or microdialysis techniques to assess the potency and efficacy of 4C-MAR as a releasing agent compared to reuptake inhibition.
• Halogen SAR Investigations: Systematically comparing 4C-MAR (4-chloro) with 4F-MAR (4-fluoro), 4B-MAR (4-bromo), and 4-methylaminorex (non-halogenated) to map the impact of halogen identity (F, Cl, Br) on monoamine transporter selectivity, potency, and efficacy. This series allows researchers to correlate halogen size, electronegativity, and lipophilicity with pharmacological activity.
• Neurochemistry Research: Investigating the effects of chlorinated aminorex analogs on central nervous system neurotransmitter systems, including dopamine, norepinephrine, and serotonin pathways.
• Metabolic Stability Research: Evaluating phase I metabolism using hepatic microsomes or S9 fractions with LC-MS/MS quantification, studying how chlorine substitution affects oxidative metabolism compared to fluorine and bromine analogs.
• Analytical Reference Standard: Serving as a high-purity calibrant for forensic toxicology, wastewater analysis, or novel psychoactive substance (NPS) screening methods.
• In Vitro Neurotoxicity Screening: Assessing cytotoxicity, mitochondrial function, and oxidative stress markers in neuronal cell cultures (e.g., SH-SY5Y, primary cortical neurons) across the halogenated aminorex series.

Researchers are encouraged to consult peer-reviewed literature (e.g., Journal of Pharmacology and Experimental Therapeutics, Neuropharmacology, European Journal of Pharmacology, ACS Chemical Neuroscience) for established in vitro protocols. RChems EU does not provide research protocols but guarantees the compound’s structural integrity and purity for such applications.

Purity & Testing

Reproducibility in monoamine transporter research and neuropharmacology depends critically on compound purity. Impurities—particularly other aminorex isomers, synthetic intermediates, or degradation products—can produce false-positive signals in transporter binding assays or confound functional release measurements. That is why 99% pure 4C-MAR from RChems EU is subjected to a multi-laboratory quality control workflow:

1. High-Performance Liquid Chromatography (HPLC-DAD): Quantitative analysis at multiple wavelengths. Minimum acceptance criterion: ≥99.0% peak area purity.
2. Liquid Chromatography-Mass Spectrometry (LC-MS): Confirms molecular ion [M+H]⁺ = 211.1 and detects trace-level organic impurities down to 0.05%.
3. Nuclear Magnetic Resonance (NMR): Both proton (¹H) and carbon-13 (¹³C) NMR verify the correct oxazoline ring system, N-methyl group, and 4-chloro substitution pattern on the phenyl ring (characteristic aromatic splitting patterns). Any spectral deviation—particularly signals indicative of incorrect substitution—triggers batch rejection.
4. Residual Solvent Analysis (GC-MS): Ensures compliance with ICH limits for Class 2 and Class 3 solvents.
5. Heavy Metal Testing (ICP-MS): Confirms levels below 20 ppm for lead, arsenic, cadmium, and mercury.

Each batch is assigned a unique lot number, and a Certificate of Analysis (COA) is available upon request. This rigorous testing ensures that when you buy 4C-MAR for research, you receive a compound that performs consistently from order to order.

Safety & Handling Guidelines

⚠️ FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

• Personal Protective Equipment (PPE): Always wear nitrile gloves, a lab coat, and chemical splash goggles when handling 4C-MAR powder.
• Engineering Controls: Use a certified chemical fume hood or glove box to prevent inhalation of airborne particulates.
• First Aid Measures:
  • Inhalation: Remove to fresh air. If breathing difficulty persists, seek medical attention.
  • Skin Contact: Wash with soap and copious water for 15 minutes. Remove contaminated clothing.
  • Eye Contact: Rinse cautiously with water for 15 minutes. Consult an ophthalmologist if irritation persists.
  • Ingestion: Do NOT induce vomiting. Rinse mouth and seek immediate medical attention.
• Spill Management: Vacuum or sweep gently (avoid generating dust). Collect in a sealed, labeled container for hazardous waste disposal.
• Storage: Store in a tightly sealed, amber glass vial at room temperature (20–25°C) in a desiccator, protected from light and moisture. Refer to the Material Safety Data Sheet (MSDS) for detailed handling instructions.

By purchasing from RChems EU, you confirm that you are a qualified researcher (or authorized agent) and that your facility can handle this compound safely.

Global Shipping & Discreet Delivery

RChems EU has perfected a discreet, reliable global logistics system for all research chemical orders, including 4C-MAR. We understand that confidentiality is essential for many academic and private research organizations.

What discreet delivery means for you:

• Plain Outer Packaging: Your order arrives in a non-descript padded envelope or small cardboard box. No logos, no brand names, no chemical identifiers.
• Unmarked Shipping Label: The return address uses a generic name (e.g., “L.C. Distribution” or “WH Logistics”). No reference to “RChems EU” or “4C-MAR.”
• Vacuum-Sealed Inner Bags: Each bag is heat-sealed to prevent leakage, odor, and tampering. No chemical name appears on the inner bag.
• No External Documentation: Invoices, COAs, or packing slips are sent via encrypted email only—never placed inside the parcel.

Fast worldwide delivery times (tracked):

Every shipment includes a real-time tracking number. Expedited courier options (FedEx Priority, DHL Express) are available at checkout for faster delivery (2–5 days globally).

Why Choose RChems EU?

• Stealth Packaging Experts: Over 7,000 successful shipments to 45+ countries with minimal customs interference.
• Third-Party Verified Purity: Every batch is independently tested. We do not sell unverified or “research grade” material without documentation.
• Responsive Scientific Support: Technical inquiries answered within 24 hours. Replacement policy for lost or damaged shipments (terms apply).
• No Minimum Order Quantity (MOQ): Order 1 gram or 25 grams—same meticulous packaging and quality standards.
• Flexible Payment Methods: Secure cryptocurrency (BTC, ETH, USDT) and select credit card options.
• Global Compliance Awareness: We monitor international regulations and adjust shipping policies accordingly.

Legal & Safety Disclaimer

⚠️ IMPORTANT – READ CAREFULLY BEFORE PURCHASING

4C-MAR (4-Chlorine-4-methylaminorex) is sold by RChems EU strictly as a research chemical and is not for human consumption, animal testing, or any form of in vivo use without appropriate institutional ethical approval. This product is not a pharmaceutical, medicinal product, dietary supplement, or recreational substance.

Legal Status Varies by Jurisdiction: 4C-MAR may be a controlled substance or regulated analog in certain countries, states, or territories. In the United States, 4-methylaminorex is a Schedule I controlled substance, and structural analogs may be considered controlled substance analogues under the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Several European countries have specific analogue legislation or blanket scheduling for aminorex derivatives. It is your sole responsibility to verify the legal status of 4C-MAR in your country, state, or province before ordering.

By completing your purchase, you certify that:

1. You are at least 18 years of age.
2. You are a qualified researcher affiliated with a bona fide laboratory or academic institution.
3. You will use this product exclusively for lawful, laboratory-based research purposes.
4. You will not introduce this compound into the body of any human or animal.

RChems EU reserves the right to cancel any order that appears destined for non-research use or for a jurisdiction where 4C-MAR is prohibited.

FAQ Section

1. What is 4C-MAR used for in research?

4C-MAR (4-Chlorine-4-methylaminorex) is used in neuropharmacological research to study monoamine transporter interactions (dopamine, norepinephrine, and serotonin transporters), the effects of chlorination on aminorex pharmacology, and structure-activity relationships comparing halogen substitution (F, Cl, Br) on monoamine releasing agent activity. It is an essential tool for systematic SAR studies across the halogenated aminorex series.

2. Is 4C-MAR legal to buy and possess for research?

Legality depends on your jurisdiction. 4C-MAR is not explicitly scheduled at the US federal level but may be considered a controlled substance analogue under the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Many European countries have analogue legislation or specific scheduling for aminorex derivatives. You must check your local regulations before ordering. RChems EU ships on the condition that you assume full legal responsibility.

3. How discreet is the shipping from RChems EU?

Extremely discreet. All 4C-MAR orders are shipped in plain, unmarked packaging with no external branding. The shipping label uses a generic return address. Inner bags are vacuum-sealed with no chemical names or CAS numbers visible. Our stealth protocol has enabled successful deliveries to over 45 countries with a 99%+ success rate.

4. What is the guaranteed purity level of your 4C-MAR?

Every batch of 4C-MAR from RChems EU is independently tested to be ≥99% pure via HPLC-DAD, with confirmation by LC-MS and ¹H/¹³C NMR. A lot-specific Certificate of Analysis (COA) is available for every order upon request.

5. How is the 99% purity tested?

We employ a five-tier analytical protocol:

• HPLC-DAD for quantitative purity (≥99% peak area at multiple wavelengths).
• LC-MS for molecular weight confirmation ([M+H]⁺ = 211.1) and trace impurity detection down to 0.05%.
• ¹H and ¹³C NMR for structural confirmation (oxazoline ring system, N-methyl group, 4-chloro substitution pattern on the phenyl ring).
• GC-MS for residual solvent analysis (ICH compliance).
• Heavy metal testing (ICP-MS) to confirm levels below 20 ppm.

All testing is performed by an ISO 17025-accredited contract laboratory.

6. Can you ship 4C-MAR to my country (USA, UK, Germany, Australia, Canada)?

RChems EU ships 4C-MAR worldwide, including the USA, Canada, United Kingdom, Germany, France, Italy, Spain, Netherlands, Switzerland, Norway, Australia, and New Zealand. However, due to varying legal statuses of aminorex derivatives, we strongly recommend contacting our support team before ordering if you are located in Germany, Sweden, Finland, or any country with broad analogue legislation. For countries with strict import controls (e.g., Japan, Singapore, South Korea), we do not currently ship 4C-MAR.

7. How should I store 4C-MAR after delivery?

Store 4C-MAR in a tightly sealed, amber glass vial at room temperature (20–25°C) in a desiccator, protected from light and moisture. For long-term storage (>6 months), refrigeration at 4°C under inert atmosphere (argon or nitrogen) is recommended. Always allow the sealed container to reach room temperature before opening to prevent condensation. Refer to the Material Safety Data Sheet (MSDS) for complete storage and handling instructions.

8. What is the difference between 4C-MAR, 4F-MAR, and 4B-MAR?

These are halogen-substituted analogs of 4-methylaminorex with different halogens at the 4-position:

• 4F-MAR has a fluorine atom (smallest halogen, strongest electronegativity, most electron-withdrawing)
• 4C-MAR has a chlorine atom (intermediate size and electronegativity)
• 4B-MAR has a bromine atom (largest halogen, most polarizable, most lipophilic)

Comparing these three compounds allows researchers to systematically investigate how halogen size, electronegativity, and lipophilicity affect monoamine transporter binding, selectivity, potency, and efficacy. This is a classic SAR study comparing halogen substitution across the periodic table (F, Cl, Br) while keeping the aminorex core constant. 4C-MAR occupies the intermediate position in this series.

9. What is the mechanism of action of 4C-MAR in research models?

In in vitro research models, 4C-MAR acts primarily as a monoamine releasing agent, promoting the release of dopamine, norepinephrine, and serotonin from presynaptic terminals. This is distinct from reuptake inhibitors (such as cocaine or methylphenidate) which block transporter function without promoting release. The specific selectivity ratio for DAT vs. NET vs. SERT can be determined using neurotransmitter release assays in transfected cell lines or synaptosomal preparations. The chlorine substitution at the 4-position may influence this selectivity profile compared to fluorine, bromine, or non-halogenated analogs.

10. Why study the halogenated aminorex series (4F-MAR, 4C-MAR, 4B-MAR)?

The systematic study of halogenated analogs (F, Cl, Br) at the 4-position of the aminorex scaffold allows researchers to:

• Correlate halogen properties (size, electronegativity, lipophilicity) with pharmacological activity
• Determine the optimal halogen for specific monoamine transporter selectivity profiles
• Understand how electronic effects vs. steric effects influence transporter binding and releasing activity
• Predict the pharmacological profile of novel halogenated analogs
• Establish structure-activity relationships that guide the design of future research compounds

This series represents a powerful SAR model for understanding halogen substitution effects in monoamine releasing agents.

11. Do you offer a reshipment policy if customs seizes my package?

Yes. RChems EU offers a one-time reshipment policy for confirmed customs seizures in most countries, provided that the original shipping address is valid and the buyer did not violate known local laws. Crypto payments qualify for the full reshipment guarantee. Terms and conditions apply—please contact customer support for details.

12. Can I get a Certificate of Analysis (COA) before ordering?

Absolutely. Contact our support team via email with the product name (4C-MAR or 4-Chlorine-4-methylaminorex) and your research affiliation. We will provide a redacted or full COA for the current batch, including HPLC chromatograms and NMR spectra, subject to verification of legitimate research intent.

Ready to advance your chlorinated aminorex and monoamine transporter SAR research? Order high-purity 4C-MAR from RChems EU today and experience unmatched product quality, stealth global delivery, and professional scientific support. Buy 4C-MAR for Research

RChems EU – Your trusted global supplier of 99% pure research chemicals.