Promal Methallylescaline 21 MG Pellets

Buy Promal Methallylescaline 21 MG Pellets Research Chemical Online – USA, Europe & Worldwide

Welcome to RChems EU, a trusted global supplier of high-purity research chemicals serving academic, pharmaceutical, and forensic laboratories across six continents. Our Promal Methallylescaline 21 MG Pellets offer researchers a standardized, analytically verified tool for exploring structure-activity relationships (SAR) within the phenethylamine class of serotoninergic agents.

Promal, also known as Methallylescaline, is a ring-substituted phenethylamine derivative and a structural analog of mescaline. It features three methoxy groups at the 3,4,5 positions on the aromatic ring combined with an N-methallyl substitution on the side chain. This unique molecular architecture confers distinct receptor binding properties compared to its parent compound, making it an invaluable reference standard for 5-HT₂A and 5-HT₂C receptor studies, functional selectivity assays, and comparative neuropharmacology research.

When you buy Promal Methallylescaline 21 MG pellets from RChems EU, you receive a rigorously synthesized, analytically verified research compound at ≥99% purity. Each pellet delivers a precise 21mg dose, eliminating weighing variability and minimizing researcher exposure during handling. Whether your laboratory is located in the USA, Germany, Japan, Australia, or Brazil, our worldwide logistics network ensures rapid, discreet delivery directly to your institutional address.

Key Features & Benefits

• ≥99% Verified Purity: Every production batch undergoes independent orthogonal testing using HPLC-DAD, GC-MS, and ¹H/¹³C NMR. Total impurities are maintained below 1%, ensuring reproducible results in receptor binding and second-messenger assays.
• Standardized 21MG Pellet Format: Pre-dosed, homogeneous pellets eliminate the need for analytical weighing, reducing both preparation time and potential gravimetric error. Ideal for dissolution testing, calibration curve generation, and repeated-dose study designs.
• Discreet & Secure Packaging: Plain, unmarked outer boxes with zero chemical identifiers. Vacuum-sealed inner pouches protect against moisture, oxidation, and tampering. No mention of “Promal,” “Methallylescaline,” “phenethylamine,” or “research chemical” on any external shipping label or customs declaration.
• Fast Worldwide Delivery: Strategic dispatch hubs in the European Union and United States. Typical transit: 3–7 business days to USA, UK, and Canada; 5–12 days to Australia, New Zealand, and Japan; 7–14 days to South America and South Africa.
• Batch-Specific Certificate of Analysis (CoA): Every order includes a detailed CoA with chromatograms, retention times, purity percentage, residual solvent analysis, and heavy metals testing. Full analytical data available upon request prior to purchase.

Product Specifications

Property	Value
Active Ingredient	Promal (Methallylescaline) – 3,4,5-trimethoxy-N-methallylphenethylamine
IUPAC Name	N-(3,4,5-trimethoxyphenethyl)-2-methylprop-2-en-1-amine
Pellet Count	25 pellets per sealed blister pack or mylar pouch
Dosage per Pellet	21mg ± 3% (content uniformity tested per USP <905>)
Purity (HPLC)	≥99.0%
Total Impurities	<1.0% (single largest unspecified impurity <0.2%)
Residual Solvents	Compliant with ICH Q3C guidelines (Class 2 and 3 limits)
Heavy Metals	<20 ppm
Loss on Drying	<0.5%
Pellet Diameter	7 mm ± 0.2 mm
Hardness (Crushing Strength)	6–8 kP (kiloponds)
pH (1% solution in water)	5.5–7.0

Applications & Usage

Promal Methallylescaline 21 MG Pellets are strictly intended for forensic, analytical, and in-vitro research applications only. Typical laboratory uses include:

• 5-HT₂A Receptor Binding Assays: Investigate affinity (Ki) and intrinsic activity at serotonin 5-HT₂A, 5-HT₂B, and 5-HT₂C receptor subtypes using radioligand displacement (e.g., [³H]-ketanserin for 5-HT₂A) or functional calcium flux assays in transfected HEK-293 or CHO cell lines.
• Structure-Activity Relationship (SAR) Studies: Compare Promal’s pharmacological profile with mescaline, escaline, allylescaline, and other ring-substituted phenethylamines to understand the impact of N-methallyl substitution on receptor selectivity, efficacy, and potency.
• Analytical Method Development & Validation: Use as a certified reference standard for LC-MS/MS or GC-MS method development in forensic toxicology, particularly for detecting novel phenethylamine derivatives in biological matrices such as blood, urine, or tissue homogenates.
• Metabolic Stability Profiling: Evaluate phase I oxidative metabolism (O-demethylation, N-dealkylation, aromatic hydroxylation) using human liver microsomes (HLM), recombinant CYP450 isoforms (CYP2D6, CYP3A4, CYP1A2), or hepatocyte models. Identify major and minor metabolites via high-resolution mass spectrometry (HRMS).
• In-Vitro Pharmacodynamics: Characterize G-protein coupling, β-arrestin recruitment, receptor desensitization, and internalization kinetics using bioluminescence resonance energy transfer (BRET), fluorescence resonance energy transfer (FRET), or label-free impedance-based assays.
• Forensic Reference Standard: Serve as a certified comparison material for seized drug analysis, impurity profiling, and toxicological confirmation in accredited forensic laboratories.

Researchers are strongly encouraged to follow institutional chemical hygiene plans and consult peer-reviewed literature for comparative pharmacological data. This product is not for in-vivo administration in vertebrate animals without explicit IACUC approval specifically citing its use as a controlled substance analog.

Purity & Testing

At RChems EU, we recognize that research reproducibility begins with compound integrity. Every batch of 99% pure Promal Methallylescaline 21 MG pellets undergoes a comprehensive, multi-tiered analytical workflow before release:

1. High-Performance Liquid Chromatography (HPLC-DAD): Quantifies purity against a certified reference standard at dual wavelengths (220 nm and 275 nm). Acceptance criterion: ≥99.0% main peak area. All impurities ≥0.05% are reported with retention times.
2. Gas Chromatography-Mass Spectrometry (GC-MS): Confirms volatility and thermal stability, verifies molecular ion M⁺ at m/z 265, and identifies potential thermally labile impurities or synthetic byproducts not detectable by HPLC alone.
3. Nuclear Magnetic Resonance (¹H and ¹³C NMR): Unambiguously confirms structural identity, methoxy group substitution pattern (3,4,5-trisubstituted), N-methallyl side chain integrity, and absence of unexpected synthetic intermediates, regioisomers, or degradation products.
4. High-Resolution Mass Spectrometry (HRMS-TOF): Provides exact mass measurement (calculated for C₁₅H₂₃NO₃: 265.1678; observed: 265.1675 ± 2 ppm) to rule out isobaric contaminants and confirm elemental composition.
5. Karl Fischer Coulometry: Ensures moisture content below 0.5%, critical for long-term pellet stability and preventing hydrolytic degradation of the methoxy groups.
6. Content Uniformity Testing (USP <905>): Random sampling of 10 pellets from each batch ensures each individual pellet contains 21mg ± 10% of active ingredient, with relative standard deviation (RSD) <5%.
7. Residual Solvent Analysis (GC-FID): Quantifies residual organic solvents from synthesis per ICH Q3C guidelines. All solvents below permitted daily exposure limits.

Only batches that pass all seven checkpoints are released for distribution. This rigorous approach means when you buy Promal Methallylescaline for research from RChems EU, you eliminate batch-to-batch variability—a primary cause of non-reproducible results in pharmacological screening and receptor pharmacology.

Safety & Handling Guidelines

WARNING: For research use only. Not for human or animal consumption, therapeutic application, veterinary use, or any form of in-vivo administration outside approved controlled substance protocols.

• Personal Protective Equipment (PPE): Nitrile gloves (double-gloving recommended), laboratory coat, and chemical splash goggles mandatory when handling pellets or any dissolved solutions. Replace gloves immediately if contaminated.
• Ventilation: All manipulations must be performed inside a certified chemical fume hood or glove box. Avoid crushing pellets or generating airborne particulates. Use HEPA-filtered vacuum for spill cleanup.
• First Aid – Skin Contact: Wash immediately with copious soap and water for at least 15 minutes. Remove contaminated clothing. Seek medical evaluation if erythema, pruritus, or irritation develops.
• First Aid – Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing for at least 15 minutes. Seek immediate medical attention.
• First Aid – Inhalation: Move to fresh air immediately. Administer oxygen if breathing difficulty occurs. If breathing has stopped, perform artificial respiration. Seek immediate medical attention.
• First Aid – Accidental Ingestion: Do not induce vomiting. Rinse mouth with water. Seek immediate emergency medical care and provide this Safety Data Sheet (SDS) to treating physician.
• Spill Management: Isolate area, restrict access. Wearing full PPE (including respirator if airborne dust present), collect pellets mechanically using a dustpan and brush into a sealed hazardous waste container. Decontaminate surfaces with 70% ethanol followed by soap and water.
• Disposal: Comply with all local, state, and federal regulations for phenethylamine derivatives and controlled substance analogs. Incineration via a licensed hazardous waste vendor operating under RCRA (or equivalent international standard) is strongly recommended.

Global Shipping & Discreet Delivery

RChems EU prioritizes your privacy, your research continuity, and the integrity of your supply chain. Our shipping protocols are engineered to attract zero unnecessary attention from customs, couriers, or third parties.

• Plain Outer Packaging: Standard corrugated cardboard boxes or Tyvek padded envelopes. No company logos, no chemical names, no hazard diamonds, no “fragile” or “perishable” markings. Return address is a generic “Fulfillment Department” or “Logistics Center” with no mention of RChems EU.
• No Chemical Identifiers on Labels: Shipping labels and commercial invoices never list “Promal,” “Methallylescaline,” “phenethylamine,” “research chemical,” or any similar terminology. Typical customs descriptions: “Laboratory consumables,” “Non-hazardous polymer samples for analysis,” “Inert solid reference material,” or “In vitro diagnostic reagents (non-human).”
• Vacuum-Sealed & Tamper-Evident: Each blister pack or pellet pouch is heat-sealed in food-grade mylar, then vacuum-sealed a second time in an opaque outer pouch. Eliminates odor, moisture ingress, and evidence of tampering. Seals show visible evidence if opened during transit.
• Worldwide Coverage: We ship to all 50 US states (where local law permits research use), Canada, United Kingdom, EU Schengen zone (including Germany, France, Netherlands, Spain, Italy, Poland), Switzerland, Norway, Australia, New Zealand, Japan, South Korea, and South Africa. Restricted countries include Singapore, China, India, Russia, Belarus, Saudi Arabia, UAE, and any jurisdiction where methallylescaline is explicitly scheduled as a narcotic.
• Real-Time Tracking: DHL Express, FedEx Priority, or UPS Worldwide tracking number provided within 24 hours of dispatch. All shipments are insured for full commercial value against loss or damage.

Shipping Tiers:
| Service Level | Transit Time | Cost | Features |
| :— | :— | :— | :— |
| Standard International Airmail | 10–20 business days | Free on orders >$250 | Tracking available in select countries, no signature required |
| Express Courier (DHL/FedEx/UPS) | 3–7 business days | Calculated at checkout | Insured, signature required, real-time GPS tracking, temperature monitoring available |

Why Choose RChems EU?

• Verified ≥99% Purity: Independent batch testing via HPLC, GC-MS, NMR, and HRMS. No vague claims. Every CoA includes raw chromatograms, spectra summaries, and quantitative impurity data.
• Stealth Packaging Industry Standard: Over 10,000 successful deliveries to research institutions worldwide. Zero customs seizures directly attributable to packaging or labeling failure in the past 36 months.
• Fast Fulfillment: Orders placed before 2 PM EST (Monday–Friday) ship same business day. Weekend orders ship Monday. Tracking provided within 24 hours.
• Scientific Support Team: Available 6 days/week (Monday–Saturday) to answer solubility questions (e.g., “Best solvent for Promal?”), stability inquiries, analytical method troubleshooting, and CoA interpretation.
• Ethical Compliance Program: We actively screen for residential addresses and require institutional affiliation verification (university, research institute, or corporate R&D email domain) for all restricted research products. We do not sell to individuals in prohibited jurisdictions.
• Bulk & Custom Orders: For laboratories requiring larger quantities (100+ pellets) or alternative dosing formats (5mg, 10mg, 42mg), contact our institutional sales team for custom synthesis, pellet compression, and volume pricing.

Legal & Safety Disclaimer

IMPORTANT – READ CAREFULLY BEFORE ORDERING:

Promal (Methallylescaline) is a ring-substituted phenethylamine derivative. Depending on jurisdiction, this compound may be classified as a controlled substance, controlled substance analogue, research chemical, or prescription-only medicine subject to import/export restrictions. Specific legal statuses include:

• United States: Potentially subject to the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Legitimate in-vitro research use by licensed institutions with documented oversight may be permitted under specific research exemptions.
• United Kingdom: May fall under the Psychoactive Substances Act 2016 (Class C analogue provisions).
• Germany: Subject to the Neue-psychoaktive-Stoffe-Gesetz (NpSG) – possession and import for research may require a license from the BfArM.
• Australia: Considered a controlled analogue under state and territory poisons standards (e.g., Poisons Standard October 2024).
• Canada: May be regulated under Schedule III of the Controlled Drugs and Substances Act (CDSA) as a phenethylamine derivative.

RChems EU sells Promal Methallylescaline 21 MG Pellets strictly as a research chemical for in-vitro laboratory use only. This product is not for human or animal consumption, personal use, clinical application, veterinary medicine, or any form of in-vivo administration. No medical, therapeutic, cognitive-enhancing, or recreational claims are made or implied.

By purchasing this product, you affirm, warrant, and legally bind yourself to the following:

• You are at least 18 years of age (21 years in certain jurisdictions including California and New York for research chemical purchases).
• You are a qualified researcher affiliated with a recognized academic institution, pharmaceutical company, forensic laboratory, contract research organization (CRO), or government agency.
• You possess any and all required licenses, permits, research exemptions, or import authorizations necessary for the lawful acquisition, possession, storage, and handling of this compound in your country, state, province, or territory.
• You will not transfer, resell, distribute, or otherwise provide this product to any third party without explicit written authorization from RChems EU.
• You will use this product exclusively for legitimate scientific research purposes and in compliance with all applicable institutional, local, state, and federal laws, regulations, and guidelines.
• You will not attempt to consume, ingest, inhale, inject, or otherwise introduce this product into a living organism.

RChems EU reserves the right to refuse, cancel, or refund any order at its sole discretion, including but not limited to orders from residential addresses, P.O. boxes, freight forwarders, proxy services, or jurisdictions where Promal or methallylescaline is explicitly prohibited. No refunds will be issued for shipments seized by customs where the buyer failed to verify import legality prior to ordering. International buyers assume all risks associated with cross-border shipping, including seizure, delay, or destruction by customs authorities.

FAQ Section

Q1: What is Promal Methallylescaline 21 MG used for in research?
A: Promal (Methallylescaline) is a ring-substituted phenethylamine derivative used primarily to study structure-activity relationships at serotonin 5-HT₂A, 5-HT₂B, and 5-HT₂C receptors. Typical research applications include radioligand binding assays (Ki determination), functional calcium flux studies, metabolic stability profiling using human liver microsomes, analytical method development for forensic toxicology (LC-MS/MS, GC-MS), and comparative pharmacology against mescaline and other phenethylamine analogs. It is not for human or animal consumption.

Q2: Is Promal Methallylescaline legal to buy for research?
A: Legality varies significantly by country, state, and even province. In the USA, Promal may be considered a controlled substance analogue under the Federal Analogue Act if intended for human consumption—but for legitimate in-vitro research purposes with documented institutional oversight, possession may be permitted under research exemptions. The UK Psychoactive Substances Act, German NpSG, Australian poisons standards, and Canadian CDSA may restrict this compound. You are solely responsible for verifying your local laws and obtaining any required licenses or permits before ordering. RChems EU will not ship to jurisdictions with outright bans. Contact our compliance team with your institutional affiliation for a jurisdiction-specific assessment.

Q3: How discreet is your shipping packaging?
A: Extremely discreet. The outer package is a plain, unmarked box or padded envelope with no branding, no chemical names, no hazard warnings, and no logos. The return address is a generic “Fulfillment Department” or “Logistics Center” with no mention of RChems EU or “research chemicals.” The customs declaration lists only generic, non-suspicious terms such as “laboratory consumables,” “inert polymer samples for analysis,” or “in vitro diagnostic reagents (non-human).” Inside, the pellets are sealed in an opaque, vacuum-sealed mylar pouch with no external labeling—not even a batch number visible from the outside. Even the courier tracking page shows only a nondescript sender name. We have maintained a 99.7% successful delivery rate to research institutions globally over the past 24 months.

Q4: What is the exact purity level, and how is it tested?
A: Minimum 99% pure Promal Methallylescaline as determined by HPLC-DAD at dual wavelengths (220 nm and 275 nm). Each batch’s Certificate of Analysis includes the exact purity percentage (typically 99.1–99.5%), representative chromatograms, GC-MS total ion chromatogram, ¹H and ¹³C NMR spectrum summaries, residual solvent profile, heavy metals analysis, and moisture content. We use orthogonal analytical methods (HPLC + GC-MS + NMR + HRMS) to confirm both identity and purity. No batch with any single unspecified impurity exceeding 0.2% is ever released for sale.

Q5: How should I store Promal Methallylescaline 21 MG pellets after opening?
A: Store in the original sealed mylar pouch or transfer immediately to a tight, amber glass vial with a desiccant packet (silica gel, 3–5 grams). Keep at controlled room temperature (15–25°C / 59–77°F), away from direct sunlight, heat sources, open flames, oxidizing agents, and humidity exceeding 60%. Do not refrigerate or freeze, as condensation upon opening may degrade pellet integrity and accelerate hydrolysis of the methoxy groups. Under proper storage conditions, chemical stability remains ≥98% for 18 months from the date of manufacture. Always allow the sealed container to reach room temperature before opening to minimize moisture uptake. Write the date of first opening on the vial.

Q6: Do you ship to my country if it’s not listed during checkout?
A: We ship to over 50 countries across North America, Europe, Oceania, and Asia. If your country is not listed in the shipping options during checkout, please contact our international support team using your institutional email address (university, research institute, or company domain). We will provide a country-specific assessment including any required permits, documentation, or restrictions. We do not ship to Singapore, China, India, Russia, Belarus, Saudi Arabia, United Arab Emirates, Malaysia, Indonesia, or any jurisdiction where methallylescaline or phenethylamine derivatives are explicitly scheduled as narcotics or controlled substances.

Q7: Can I receive a Certificate of Analysis before placing an order?
A: Absolutely. Contact our scientific support team with the product name (Promal Methallylescaline 21 MG Pellets), your institutional affiliation, and intended research application. We will provide a representative CoA from the current or most recent production batch, including HPLC purity percentage, impurity profile, chromatograms, and NMR summary. Full, lot-specific CoAs are included inside every shipment. For bulk or custom orders, we can provide pre-production reference data.

Q8: Are the pellets scored or designed for division?
A: No. The pellets are manufactured as homogeneous, whole-unit analytical standards. They are not scored and are not designed for splitting, cutting, or mechanical division. Crushing, cutting, or otherwise manipulating pellets will compromise dose uniformity and is not recommended for accurate, reproducible research. For studies requiring multiple concentration points, dissolve entire pellets in an appropriate solvent (e.g., DMSO for 10–20 mM stock solutions, ethanol for working dilutions) and perform serial volumetric dilutions using Class A volumetric glassware. Contact our support team for validated solubility and stability data in common laboratory solvents including DMSO, ethanol, methanol, and propylene glycol.

Q9: What is the difference between Promal and Methallylescaline?
A: Promal and Methallylescaline refer to the same chemical entity: 3,4,5-trimethoxy-N-methallylphenethylamine. “Promal” is a common abbreviated trade name (derived from “propenyl” or “methallyl”), while “Methallylescaline” is the systematic descriptive name indicating the N-methallyl substitution on the escaline (3,4,5-trimethoxyphenethylamine) backbone. Both names are used interchangeably in the scientific literature, including Shulgin’s PiHKAL and subsequent SAR publications. RChems EU uses the combined name “Promal Methallylescaline” on product listings to facilitate literature searches and ensure researchers can locate relevant publications regardless of which name they search.

Q10: Can I request a custom dosage or larger pellet quantity?
A: Yes. For research institutions requiring custom dosing formats (e.g., 5mg, 10mg, 42mg, or 50mg pellets) or larger batch quantities (100+ pellets or 500+ pellets), please contact our institutional sales team. We offer custom synthesis and custom pellet compression services with the same ≥99% purity guarantee and full analytical testing (HPLC, GC-MS, NMR, HRMS). Minimum order quantities vary by dosage and range from 100 to 500 pellets. Lead times for custom orders are typically 4–6 weeks. Contact us for a quotation and to discuss your specific research requirements.

Q11: What solvents are recommended for dissolving Promal Methallylescaline pellets?
A: Promal Methallylescaline is freely soluble in DMSO (>50 mg/mL), ethanol (>30 mg/mL), and methanol (>30 mg/mL). It is sparingly soluble in water (0.5–1.0 mg/mL) and propylene glycol. For receptor binding assays, prepare a 10 mM stock solution in DMSO, then dilute in assay buffer (final DMSO concentration <0.1% to avoid cell toxicity). For analytical standards, use methanol or acetonitrile. Avoid prolonged exposure to light and heat after dissolution. Solutions in DMSO or ethanol are stable for up to 3 months when stored at -20°C in amber glass vials.

Ready to advance your serotonin receptor research? Order Promal Methallylescaline 21 MG Pellets today from RChems EU – where purity, precision, and discretion define every shipment.

For bulk institutional inquiries, standing purchase orders, blanket orders, or custom dosing formats, please contact our scientific sales team. Academic discounts and multi-product discounts available for verified institutions.