Etizolam Pure

Buy Etizolam Pure Research Chemical Online – USA, Europe & Worldwide

The thienodiazepine class of research chemicals has garnered significant attention in neuropharmacology due to their high-affinity interactions with the benzodiazepine binding site on GABA-A receptors. Etizolam Pure —scientifically designated as 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine—is a potent thienodiazepine derivative distinguished by a thiophene ring fused to the diazepine core, in contrast to the benzene ring found in classical benzodiazepines such as diazepam or alprazolam. This structural modification confers distinct electronic and steric properties that influence receptor binding kinetics and metabolic stability.

Etizolam is registered under CAS number 40054-69-1, providing unambiguous chemical identification for research documentation. For researchers investigating the molecular pharmacology of GABA-A receptor subtypes, the structure-activity relationships of thienodiazepines versus classical benzodiazepines, and the effects of heterocyclic ring substitutions on receptor binding and functional activity, Etizolam offers a distinct chemical probe. When you buy Etizolam Pure from RChems EU, you acquire a high-purity research compound manufactured under strict quality controls. Our 99% pure Etizolam is intended exclusively for laboratory research—not for human or animal consumption—enabling precise, reproducible experiments in receptor pharmacology, neurochemistry, and behavioral neuroscience.

Key Features & Benefits

• Verified 99%+ Purity: Every batch undergoes independent HPLC, LC-MS, and ¹H/¹³C NMR analysis to guarantee ≥99% purity.
• Thienodiazepine Derivative: Enables SAR studies comparing thiophene-ring-containing thienodiazepines with classical benzene-ring benzodiazepines on GABA-A receptor binding affinity and selectivity.
• 2-Chlorophenyl Substitution: The chlorine atom at the 2-position of the phenyl ring alters electronic properties and receptor binding compared to non-halogenated analogs.
• Positive Allosteric Modulator: Acts at the benzodiazepine binding site on GABA-A receptors, enhancing GABA-induced chloride channel conductance.
• CAS-Identified Compound: Registered under CAS number 40054-69-1 for unambiguous chemical identification.
• Well-Documented Research History: Extensively characterized in peer-reviewed literature with abundant reference data for assay development.
• Worldwide Delivery: Fast, tracked shipping to the USA, Canada, Europe, Australia, and select Asian research hubs.
• Discreet Packaging Protocol: Plain outer boxes, unmarked labels, vacuum-sealed inner bags—no chemical names on the parcel.

Product Specifications

Property	Specification
IUPAC Name	4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number	40054-69-1
Synonyms	Etizolam, Etizola, Depas (research reference)
Physical State	Crystalline powder
Purity Analysis	HPLC (≥99%), LC-MS, ¹H/¹³C NMR
Loss on Drying	<0.5%
Residual Solvents	Compliant with ICH Q3C guidelines
Heavy Metals	<20 ppm
Chemical Class	Thienodiazepine / GABA-A receptor positive allosteric modulator

Applications & Usage

⚠️ Strictly for laboratory research use only. Not for human or animal consumption.

Etizolam Pure is utilized in a range of non-clinical, pre-clinical, and basic science research applications. Typical areas of investigation include:

• GABA-A Receptor Binding Assays: Evaluating affinity (Ki) for the benzodiazepine binding site on GABA-A receptor subtypes (α1β2γ2, α2β3γ2, α3β3γ2, α5β3γ2) using radioligand displacement (e.g., [³H]flumazenil or [³H]Ro15-1788) in rat brain homogenates or transfected cell lines.
• Positive Allosteric Modulation Functional Studies: Measuring GABA-induced chloride influx or electrophysiological recordings (patch-clamp) to assess the potency and efficacy of Etizolam as a positive allosteric modulator across different GABA-A receptor subunit combinations.
• Thienodiazepine vs. Benzodiazepine SAR Investigations: Systematically comparing Etizolam (thiophene ring) with classical benzodiazepines such as alprazolam or diazepam (benzene ring) to map the impact of heterocyclic ring substitution on receptor subtype selectivity, intrinsic efficacy, and metabolic stability.
• Metabolic Stability Research: Evaluating phase I and phase II metabolism using hepatic microsomes or S9 fractions with LC-MS/MS quantification, particularly studying the unique metabolic pathways of the thiophene ring compared to benzene-ring benzodiazepines.
• Analytical Reference Standard: Serving as a high-purity calibrant for forensic toxicology, wastewater analysis, or novel psychoactive substance (NPS) screening methods.
• In Vitro Neurotoxicity Screening: Assessing cytotoxicity, mitochondrial function, and oxidative stress markers in neuronal cell cultures (e.g., SH-SY5Y, primary cortical neurons).

Researchers are encouraged to consult peer-reviewed literature (e.g., Journal of Medicinal Chemistry, Neuropharmacology, European Journal of Pharmacology, Psychopharmacology) for established in vitro protocols. RChems EU does not provide research protocols but guarantees the compound’s structural integrity and purity for such applications.

Purity & Testing

Reproducibility in GABA-A receptor and neuropharmacology research depends critically on compound purity. Impurities—particularly other thienodiazepine isomers, synthetic intermediates, or degradation products—can produce false-positive signals in receptor binding assays or confound functional readouts. That is why 99% pure Etizolam from RChems EU is subjected to a multi-laboratory quality control workflow:

1. High-Performance Liquid Chromatography (HPLC-DAD): Quantitative analysis at 220 nm and 254 nm. Minimum acceptance criterion: ≥99.0% peak area purity.
2. Liquid Chromatography-Mass Spectrometry (LC-MS): Confirms molecular ion [M+H]⁺ = 343.1 and detects trace-level organic impurities down to 0.05%.
3. Nuclear Magnetic Resonance (NMR): Both proton (¹H) and carbon-13 (¹³C) NMR verify the correct thienodiazepine ring system, 2-chlorophenyl substitution (characteristic aromatic splitting), and ethyl and methyl substituents. Any spectral deviation—particularly signals indicative of incorrect substitution—triggers batch rejection.
4. Residual Solvent Analysis (GC-MS): Ensures compliance with ICH limits for Class 2 and Class 3 solvents.
5. Heavy Metal Testing (ICP-MS): Confirms levels below 20 ppm for lead, arsenic, cadmium, and mercury.

Each batch is assigned a unique lot number, and a Certificate of Analysis (COA) is available upon request. This rigorous testing ensures that when you buy Etizolam Pure for research, you receive a compound that performs consistently from order to order.

Safety & Handling Guidelines

⚠️ FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

• Personal Protective Equipment (PPE): Always wear nitrile gloves, a lab coat, and chemical splash goggles when handling Etizolam powder.
• Engineering Controls: Use a certified chemical fume hood or glove box to prevent inhalation of airborne particulates.
• First Aid Measures:
  • Inhalation: Remove to fresh air. If breathing difficulty persists, seek medical attention.
  • Skin Contact: Wash with soap and copious water for 15 minutes. Remove contaminated clothing.
  • Eye Contact: Rinse cautiously with water for 15 minutes. Consult an ophthalmologist if irritation persists.
  • Ingestion: Do NOT induce vomiting. Rinse mouth and seek immediate medical attention.
• Spill Management: Vacuum or sweep gently (avoid generating dust). Collect in a sealed, labeled container for hazardous waste disposal.
• Storage: Store in a tightly sealed, amber glass vial at room temperature (20–25°C) in a desiccator or under refrigeration (4°C) for long-term storage. Allow to equilibrate to room temperature before opening to prevent condensation.

By purchasing from RChems EU, you confirm that you are a qualified researcher (or authorized agent) and that your facility can handle this compound safely.

Global Shipping & Discreet Delivery

RChems EU has perfected a discreet, reliable global logistics system for all research chemical orders, including Etizolam Pure. We understand that confidentiality is essential for many academic and private research organizations.

What discreet delivery means for you:

• Plain Outer Packaging: Your order arrives in a non-descript padded envelope or small cardboard box. No logos, no brand names, no chemical identifiers.
• Unmarked Shipping Label: The return address uses a generic name (e.g., “L.C. Distribution” or “WH Logistics”). No reference to “RChems EU” or “Etizolam.”
• Vacuum-Sealed Inner Bags: Each bag is heat-sealed to prevent leakage, odor, and tampering. No chemical name appears on the inner bag.
• No External Documentation: Invoices, COAs, or packing slips are sent via encrypted email only—never placed inside the parcel.

Fast worldwide delivery times (tracked):

Region	Estimated Transit Time
USA & Canada	5–9 business days
Europe (UK, Germany, France, Spain, Italy, Netherlands)	3–7 business days
Australia & New Zealand	7–12 business days
Rest of World (select countries)	7–14 business days

Every shipment includes a real-time tracking number. Expedited courier options (FedEx Priority, DHL Express) are available at checkout for faster delivery (2–5 days globally).

Why Choose RChems EU?

• Stealth Packaging Experts: Over 7,000 successful shipments to 45+ countries with minimal customs interference.
• Third-Party Verified Purity: Every batch is independently tested. We do not sell unverified or “research grade” material without documentation.
• Responsive Scientific Support: Technical inquiries answered within 24 hours. Replacement policy for lost or damaged shipments (terms apply).
• No Minimum Order Quantity (MOQ): Order 10 grams or 1000 grams—same meticulous packaging and quality standards.
• Flexible Payment Methods: Secure cryptocurrency (BTC, ETH, USDT) and select credit card options.
• Global Compliance Awareness: We monitor international regulations and adjust shipping policies accordingly.

Legal & Safety Disclaimer

⚠️ IMPORTANT – READ CAREFULLY BEFORE PURCHASING

Etizolam Pure is sold by RChems EU strictly as a research chemical and is not for human consumption, animal testing, or any form of in vivo use without appropriate institutional ethical approval. This product is not a pharmaceutical, medicinal product, dietary supplement, or recreational substance.

Legal Status Varies by Jurisdiction: Etizolam (CAS 40054-69-1) may be a controlled substance or regulated analog in certain countries, states, or territories. In the United States, it is not federally scheduled but may be considered a controlled substance analogue under the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Several countries (including Japan, China, and many European nations) have specific legislation controlling thienodiazepines. It is your sole responsibility to verify the legal status of Etizolam in your country, state, or province before ordering.

By completing your purchase, you certify that:

1. You are at least 18 years of age.
2. You are a qualified researcher affiliated with a bona fide laboratory or academic institution.
3. You will use this product exclusively for lawful, laboratory-based research purposes.
4. You will not introduce this compound into the body of any human or animal.

RChems EU reserves the right to cancel any order that appears destined for non-research use or for a jurisdiction where Etizolam is prohibited.

FAQ Section

1. What is Etizolam Pure used for in research?

Etizolam Pure (CAS 40054-69-1) is used in neuropharmacological research to study GABA-A receptor binding affinity and positive allosteric modulation, the effects of thiophene ring substitution (vs. benzene ring in classical benzodiazepines) on receptor pharmacology, and structure-activity relationships among thienodiazepine derivatives. Typical applications include radioligand binding assays, electrophysiological studies (patch-clamp), and metabolic stability research.

2. Is Etizolam legal to buy and possess for research?

Legality depends on your jurisdiction. Etizolam is not federally scheduled in the United States but may be considered a controlled substance analogue under the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Several countries (including Japan, China, Germany, Italy, and the UK) have specific controls on Etizolam. You must check your local regulations before ordering. RChems EU ships on the condition that you assume full legal responsibility.

3. How discreet is the shipping from RChems EU?

Extremely discreet. All Etizolam orders are shipped in plain, unmarked packaging with no external branding. The shipping label uses a generic return address. Inner bags are vacuum-sealed with no chemical names or CAS numbers visible. Our stealth protocol has enabled successful deliveries to over 45 countries with a 99%+ success rate.

4. What is the guaranteed purity level of your Etizolam?

Every batch of Etizolam from RChems EU is independently tested to be ≥99% pure via HPLC-DAD, with confirmation by LC-MS and ¹H/¹³C NMR. A lot-specific Certificate of Analysis (COA) is available for every order upon request.

5. How is the 99% purity tested?

We employ a five-tier analytical protocol:

• HPLC-DAD for quantitative purity (≥99% peak area at 220 nm and 254 nm).
• LC-MS for molecular weight confirmation ([M+H]⁺ = 343.1) and trace impurity detection down to 0.05%.
• ¹H and ¹³C NMR for structural confirmation (thienodiazepine ring system, 2-chlorophenyl substitution, ethyl and methyl substituents).
• GC-MS for residual solvent analysis (ICH compliance).
• Heavy metal testing (ICP-MS) to confirm levels below 20 ppm.

All testing is performed by an ISO 17025-accredited contract laboratory.

6. Can you ship Etizolam to my country (USA, UK, Germany, Australia, Canada)?

RChems EU ships Etizolam worldwide, including the USA, Canada, United Kingdom, Germany, France, Italy, Spain, Netherlands, Switzerland, Norway, Australia, and New Zealand. However, due to varying legal statuses of thienodiazepines, we strongly recommend contacting our support team before ordering if you are located in Germany, Italy, Japan, or any country with specific Etizolam restrictions. For countries with strict import controls (e.g., Singapore, South Korea), we do not currently ship Etizolam.

7. How should I store Etizolam after delivery?

Store Etizolam in a tightly sealed, amber glass vial at room temperature (20–25°C) in a desiccator or under refrigeration (4°C) for long-term storage. Always allow the sealed container to reach room temperature before opening to prevent condensation. Avoid prolonged exposure to air, light, and heat.

8. What is the difference between Etizolam and classical benzodiazepines (e.g., alprazolam)?

The key structural difference is the heterocyclic ring fused to the diazepine core:

• Classical benzodiazepines (alprazolam, diazepam) have a benzene ring
• Etizolam has a thiophene ring (sulfur-containing five-membered aromatic ring)

In GABA-A receptor research, the thiophene ring substitution alters:

• Electronic properties and receptor binding affinity
• Metabolic stability and elimination pathways
• Selectivity for different GABA-A receptor subtypes
• Overall pharmacokinetic profile in research models

Comparing Etizolam with classical benzodiazepines allows researchers to map the impact of heterocyclic ring substitution on thienodiazepine vs. benzodiazepine pharmacology.

9. What is the significance of CAS number 40054-69-1?

CAS number 40054-69-1 is the unique Chemical Abstracts Service identifier for Etizolam. Researchers can use this CAS number for precise chemical identification when ordering reference standards, searching scientific literature, or documenting research materials. It is the standard identifier across analytical chemistry, forensic toxicology, and pharmacological research.

10. Do you offer a reshipment policy if customs seizes my package?

Yes. RChems EU offers a one-time reshipment policy for confirmed customs seizures in most countries, provided that the original shipping address is valid and the buyer did not violate known local laws. Crypto payments qualify for the full reshipment guarantee. Terms and conditions apply—please contact customer support for details.

11. Can I get a Certificate of Analysis (COA) before ordering?

Absolutely. Contact our support team via email with the product name (Etizolam Pure) and your research affiliation. We will provide a redacted or full COA for the current batch, including HPLC chromatograms and NMR spectra, subject to verification of legitimate research intent.

Ready to advance your GABA-A receptor and thienodiazepine research? Order high-purity Etizolam Pure from RChems EU today and experience unmatched product quality, stealth global delivery, and professional scientific support. Buy Etizolam Pure for Research.

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