Metocin 4-HO-MET 21 MG Pellets

Buy Metocin 4-HO-MET 21 MG Pellets Research Chemical Online – USA, Europe & Worldwide

Welcome to RChems EU, a globally trusted supplier of high-purity research chemicals serving academic, pharmaceutical, and forensic laboratories across five continents. Our Metocin 4-HO-MET 21 MG Pellets offer researchers a standardized, analytically verified tool for exploring the complex pharmacology of synthetic tryptamine derivatives.

Metocin, scientifically known as 4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine), is a synthetic tryptamine belonging to the same chemical family as psilocin (4-HO-DMT). It features a hydroxyl group at the 4-position of the indole ring and a substituted ethylamine side chain with methyl and ethyl groups. This unique molecular architecture makes it a valuable research tool for studying structure-activity relationships (SAR) at serotonin (5-HT) receptor subtypes, particularly the 5-HT₂A receptor, as well as the serotonin transporter (SERT). The compound was first synthesized by the renowned chemist Alexander Shulgin in the 1960s, who noted its structural similarity to psilocin but with distinct pharmacological characteristics.

When you buy Metocin 4-HO-MET 21 mg pellets from RChems EU, you receive a rigorously synthesized, analytically verified research compound at ≥98% purity. Each pellet delivers a precise 21mg dose, eliminating weighing variability and minimizing researcher exposure during handling. Whether your laboratory is located in the USA, Germany, Japan, Australia, or Brazil, our worldwide logistics network ensures rapid, discreet delivery directly to your institutional address.

Key Features & Benefits

• ≥98% Verified Purity: Every production batch undergoes independent orthogonal testing using HPLC-DAD, ¹H/¹³C NMR, and LC-MS/MS. Total impurities are maintained below 2%, ensuring reproducible results in receptor binding and functional assays.
• Standardized 21mg Pellet Format: Pre-dosed, homogeneous pellets eliminate the need for analytical weighing, reducing both preparation time and potential gravimetric error. Ideal for dissolution testing, calibration curve generation, and repeated-dose study designs.
• Discreet & Secure Packaging: Plain, unmarked outer boxes with zero chemical identifiers. Vacuum-sealed inner pouches protect against moisture, oxidation, and tampering. No mention of “Metocin,” “4-HO-MET,” “tryptamine,” or “research chemical” on any external shipping label or customs declaration.
• Fast Worldwide Delivery: Strategic dispatch hubs in the European Union and United States. Typical transit: 3–7 business days to USA, UK, and Canada; 5–12 days to Australia, New Zealand, and Japan; 7–14 days to South America and South Africa.
• Batch-Specific Certificate of Analysis (CoA): Every order includes a detailed CoA with chromatograms, retention times, purity percentage, residual solvent analysis, and heavy metals testing. Full analytical data available upon request prior to purchase.
• Flexible Quantity Options: Available in 10, 20, 30, 40, or 50 pellet quantities to suit studies of any scale.

Product Specifications

Property	Value
Active Ingredient	Metocin (4-HO-MET) – 4-hydroxy-N-methyl-N-ethyltryptamine
IUPAC Name	3-[2-(ethyl(methyl)amino)ethyl]-1H-indol-4-ol
Synonyms	4-hydroxy-N-methyl-N-ethyltryptamine; metocin
Pellet Count Options	10, 20, 30, 40, or 50 pellets per sealed pouch
Dosage per Pellet	21mg ± 3% (content uniformity tested)
Purity (HPLC)	≥98.0%
Total Impurities	<2.0% (single largest unspecified impurity <0.5%)
Inactive Ingredients	Microcrystalline cellulose, lactose, magnesium stearate, colloidal silicon dioxide, pharmaceutical excipients
Heavy Metals	<20 ppm
Loss on Drying	<0.5%
Pellet Diameter	7 mm ± 0.2 mm
Hardness (Crushing Strength)	5–7 kP

Applications & Usage

Metocin 4-HO-MET 21 MG Pellets are strictly intended for forensic, analytical, and in-vitro research applications only. Typical laboratory uses include:

• Serotonin Receptor Binding Assays: Investigate affinity (Ki) and functional activity at 5-HT₂A, 5-HT₁A, and 5-HT₂C receptor subtypes using radioligand displacement (e.g., [³H]-ketanserin for 5-HT₂A) or functional calcium flux assays in transfected HEK-293 or CHO cell lines. 4-HO-MET is known to bind to serotonin receptors, particularly the 5-HT₂A receptor, causing altered states of consciousness, perception, and mood in pharmacological models.
• Structure-Activity Relationship (SAR) Research: Compare 4-HO-MET with other 4-substituted tryptamines (e.g., psilocin/4-HO-DMT, 4-HO-MiPT, 4-AcO-DMT) to understand the impact of N-methyl-N-ethyl substitution on receptor selectivity, potency, and efficacy.
• Serotonin Transporter (SERT) Studies: Evaluate 4-HO-MET’s interaction with SERT using radioligand uptake inhibition assays ([³H]-serotonin) in synaptosomal preparations or transfected cells.
• Analytical Method Development & Validation: Employ as a certified reference standard for LC-MS/MS, GC-MS, or HPLC-DAD method development in forensic toxicology, clinical research, and workplace drug testing for tryptamine derivatives.
• Metabolic Stability Profiling: Evaluate phase I and phase II metabolism (O-glucuronidation, O-sulfation, deamination, N-dealkylation) using human liver microsomes (HLM), recombinant CYP450 isoforms (CYP2D6, CYP3A4, CYP1A2), or hepatocyte models. Identify major and minor metabolites via high-resolution mass spectrometry.
• Forensic Reference Standard: Serve as a certified comparison material for seized drug analysis, post-mortem toxicology, and impurity profiling in accredited forensic laboratories.

Researchers are strongly encouraged to follow institutional chemical hygiene plans and consult peer-reviewed literature for comparative pharmacological data. This product is not for in-vivo administration in vertebrate animals without explicit IACUC approval specifically citing its use as a research chemical.

Purity & Testing

At RChems EU, we understand that research reproducibility begins with compound integrity. Every batch of high-purity Metocin 4-HO-MET 21 mg pellets undergoes a comprehensive, multi-tiered analytical workflow before release:

1. High-Performance Liquid Chromatography (HPLC-DAD): Quantifies purity against a certified reference standard at dual wavelengths (220 nm and 280 nm). Acceptance criterion: ≥98.0% main peak area. All impurities ≥0.1% are reported with retention times.
2. Liquid Chromatography-Mass Spectrometry (LC-MS/MS): Confirms molecular ion [M+H]⁺ at m/z 219.1 and characteristic fragmentation pattern (loss of water, loss of ethyl/methyl groups). Rules out isobaric contaminants and synthetic byproducts.
3. Nuclear Magnetic Resonance (¹H and ¹³C NMR): Unambiguously confirms structural identity, including the 4-hydroxy substitution pattern and the N-methyl-N-ethyl side chain configuration. Verifies absence of unexpected synthetic intermediates or regioisomers.
4. Karl Fischer Coulometry: Ensures moisture content below 0.5%, critical for long-term pellet stability and preventing oxidative degradation of the 4-hydroxy group.
5. Content Uniformity Testing: Random sampling of 10 pellets from each batch ensures each individual pellet contains 21mg ± 10% of active ingredient, with relative standard deviation (RSD) <6%.
6. Residual Solvent Analysis (GC-FID): Quantifies residual organic solvents from synthesis per ICH Q3C guidelines.

Only batches that pass all six checkpoints are released for distribution. This rigorous approach means when you buy Metocin 4-HO-MET for research from RChems EU, you eliminate batch-to-batch variability—a primary cause of non-reproducible results in serotonin pharmacology and forensic toxicology.

Safety & Handling Guidelines

WARNING: For research use only. Not for human or animal consumption, therapeutic application, veterinary use, or any form of in-vivo administration outside approved controlled substance protocols.

• Personal Protective Equipment (PPE): Nitrile gloves (double-gloving recommended), laboratory coat, and chemical splash goggles mandatory when handling pellets or any dissolved solutions. Replace gloves immediately if contaminated.
• Ventilation: All manipulations must be performed inside a certified chemical fume hood or glove box. Avoid crushing pellets or generating airborne particulates. Use HEPA-filtered vacuum for spill cleanup.
• First Aid – Skin Contact: Wash immediately with copious soap and water for at least 15 minutes. Remove contaminated clothing. Seek medical evaluation if irritation develops.
• First Aid – Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing for at least 15 minutes. Seek immediate medical attention.
• First Aid – Inhalation: Move to fresh air immediately. Administer oxygen if breathing difficulty occurs. If breathing has stopped, perform artificial respiration. Seek immediate medical attention.
• First Aid – Accidental Ingestion: Do not induce vomiting. Rinse mouth with water. Seek immediate emergency medical care and provide this Safety Data Sheet (SDS) to treating physician.
• Spill Management: Isolate area, restrict access. Wearing full PPE, collect pellets mechanically using a dustpan and brush into a sealed hazardous waste container. Decontaminate surfaces with 70% ethanol followed by soap and water.
• Disposal: Comply with all local, state, and federal regulations for tryptamine derivatives and research chemicals. Incineration via a licensed hazardous waste vendor is strongly recommended.

Global Shipping & Discreet Delivery

RChems EU prioritizes your privacy, your research continuity, and the integrity of your supply chain. Our shipping protocols are engineered to attract zero unnecessary attention from customs, couriers, or third parties.

• Plain Outer Packaging: Standard corrugated cardboard boxes or Tyvek padded envelopes. No company logos, no chemical names, no hazard diamonds. Return address is a generic “Fulfillment Department” or “Logistics Center” with no mention of RChems EU.
• No Chemical Identifiers on Labels: Shipping labels and commercial invoices never list “Metocin,” “4-HO-MET,” “tryptamine,” “research chemical,” or any similar terminology. Typical customs descriptions: “Laboratory consumables,” “Non-hazardous solid reference material,” “Inert polymer samples for analysis,” or “In vitro diagnostic reagents (non-human).”
• Vacuum-Sealed & Tamper-Evident: Each pellet pouch is heat-sealed in food-grade mylar, then vacuum-sealed a second time in an opaque outer pouch. Eliminates moisture ingress and evidence of tampering. Seals show visible evidence if opened during transit.
• Worldwide Coverage: We ship to all 50 US states (where local law permits research use), Canada, United Kingdom, EU Schengen zone, Switzerland, Norway, Australia, New Zealand, Japan, South Korea, and South Africa.
• Real-Time Tracking: DHL Express, FedEx Priority, or UPS Worldwide tracking number provided within 24 hours of dispatch. All shipments are insured for full commercial value against loss or damage.

Shipping Tiers:
| Service Level | Transit Time | Cost | Features |
| :— | :— | :— | :— |
| Standard International Airmail | 10–20 business days | Free on orders >$250 | Tracking available in select countries, no signature required |
| Express Courier (DHL/FedEx/UPS) | 3–7 business days | Calculated at checkout | Insured, signature required, real-time GPS tracking |

Why Choose RChems EU?

• Verified High Purity: Independent batch testing via HPLC, LC-MS, and NMR. Every CoA includes raw chromatograms, spectra summaries, and quantitative impurity data.
• Stealth Packaging Industry Standard: Over 10,000 successful deliveries to research institutions worldwide. Zero customs seizures directly attributable to packaging or labeling failure in the past 36 months.
• Fast Fulfillment: Orders placed before 2 PM EST (Monday–Friday) ship same business day. Weekend orders ship Monday. Tracking provided within 24 hours.
• Scientific Support Team: Available 6 days/week (Monday–Saturday) to answer solubility questions (e.g., “Best solvent for 4-HO-MET?”), stability inquiries, analytical method troubleshooting, and CoA interpretation.
• Flexible Quantities: Choose from 10, 20, 30, 40, or 50 pellets to match your research scale.
• Ethical Compliance Program: We actively screen for residential addresses and require institutional affiliation verification (university, research institute, or corporate R&D email domain) for all restricted research products. We do not sell to individuals in prohibited jurisdictions.

Legal & Safety Disclaimer

IMPORTANT – READ CAREFULLY BEFORE ORDERING:

Metocin (4-HO-MET) is a synthetic tryptamine derivative with psychedelic properties. Depending on jurisdiction, this compound may be classified as a controlled substance, controlled substance analogue, or research chemical subject to import/export restrictions. Specific legal statuses include:

• United States: 4-HO-MET is not currently scheduled at the federal level but may be subject to the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Legitimate in-vitro research use by licensed institutions with documented oversight may be permitted.
• United Kingdom: May fall under the Psychoactive Substances Act 2016 as a Class A controlled substance analogue.
• Germany: Subject to the Neue-psychoaktive-Stoffe-Gesetz (NpSG) as a tryptamine derivative.
• Australia: Considered a controlled substance under state and territory poisons standards.
• Canada: Regulated under Schedule III of the Controlled Drugs and Substances Act (CDSA) as a tryptamine derivative.

RChems EU sells Metocin 4-HO-MET 21 MG Pellets strictly as a research chemical for in-vitro laboratory use only. This product is not for human or animal consumption, personal use, clinical application, veterinary medicine, or any form of in-vivo administration. No medical, therapeutic, psychedelic, or psychoactive claims are made or implied.

By purchasing this product, you affirm, warrant, and legally bind yourself to the following:

• You are at least 18 years of age (21 years in certain jurisdictions including California and New York for research chemical purchases).
• You are a qualified researcher affiliated with a recognized academic institution, pharmaceutical company, forensic laboratory, contract research organization (CRO), or government agency.
• You possess any and all required licenses, permits, research exemptions, or import authorizations necessary for the lawful acquisition, possession, storage, and handling of this compound in your country, state, province, or territory.
• You will not transfer, resell, distribute, or otherwise provide this product to any third party without explicit written authorization from RChems EU.
• You will use this product exclusively for legitimate scientific research purposes and in compliance with all applicable institutional, local, state, and federal laws, regulations, and guidelines.
• You will not attempt to consume, ingest, inhale, inject, or otherwise introduce this product into a living organism.

RChems EU reserves the right to refuse, cancel, or refund any order at its sole discretion, including but not limited to orders from residential addresses, P.O. boxes, freight forwarders, proxy services, or jurisdictions where 4-HO-MET is explicitly prohibited. No refunds will be issued for shipments seized by customs where the buyer failed to verify import legality prior to ordering. International buyers assume all risks associated with cross-border shipping, including seizure, delay, or destruction by customs authorities.

FAQ Section

Q1: What is Metocin 4-HO-MET 21 mg used for in research?
A: Metocin (4-HO-MET) is a synthetic tryptamine derivative and the 4-hydroxylated analog of MET. It is used to study serotonin (5-HT) receptor pharmacology, particularly 5-HT₂A, 5-HT₁A, and 5-HT₂C receptor binding affinity and functional activity. Typical research applications include receptor binding assays (radioligand displacement), structure-activity relationship (SAR) comparisons with other 4-substituted tryptamines (psilocin, 4-HO-MiPT), serotonin transporter (SERT) studies, analytical method development for forensic toxicology (LC-MS/MS, GC-MS), and metabolic stability profiling using human liver microsomes. It is not for human or animal consumption.

Q2: Is Metocin 4-HO-MET legal to buy for research?
A: Legality varies significantly by country and jurisdiction. In the USA, 4-HO-MET is not currently scheduled at the federal level but may be subject to the Federal Analogue Act if intended for human consumption—legitimate in-vitro research by licensed institutions may be permissible. The UK Psychoactive Substances Act, German NpSG, Canadian CDSA, and Australian poisons standards may regulate this compound as a controlled substance analogue. You are solely responsible for verifying your local laws and obtaining any required licenses or permits before ordering. RChems EU will not ship to jurisdictions with outright bans. Contact our compliance team with your institutional affiliation for a jurisdiction-specific assessment.

Q3: How discreet is your shipping packaging?
A: Extremely discreet. The outer package is a plain, unmarked box or padded envelope with no branding, no chemical names, no hazard warnings, and no logos. The return address is a generic “Fulfillment Department” or “Logistics Center” with no mention of RChems EU or “research chemicals.” The customs declaration lists only generic, non-suspicious terms such as “laboratory consumables,” “non-hazardous solid reference material,” or “in vitro diagnostic reagents (non-human).” Inside, the pellets are sealed in an opaque, vacuum-sealed mylar pouch with no external labeling. Even the courier tracking page shows only a nondescript sender name. We have maintained a 99.7% successful delivery rate to research institutions globally over the past 24 months.

Q4: What is the exact purity level, and how is it tested?
A: Minimum 98% pure 4-HO-MET as determined by HPLC-DAD at dual wavelengths (220 nm and 280 nm). Each batch’s Certificate of Analysis includes the exact purity percentage (typically 98.2–98.9%), representative chromatograms, LC-MS/MS total ion chromatogram, ¹H and ¹³C NMR spectrum summaries, residual solvent profile, heavy metals analysis, and moisture content. We use orthogonal analytical methods (HPLC + LC-MS + NMR) to confirm both identity and purity. No batch with any single unspecified impurity exceeding 0.5% is ever released for sale.

Q5: How should I store Metocin 4-HO-MET 21 mg pellets after opening?
A: Store in the original sealed mylar pouch or transfer immediately to a tight, amber glass vial with a desiccant packet (silica gel, 3–5 grams). Keep at controlled room temperature (15–25°C / 59–77°F), away from direct sunlight, heat sources, open flames, oxidizing agents, and humidity exceeding 60%. Do not refrigerate or freeze, as condensation upon opening may degrade pellet integrity and accelerate oxidative degradation of the 4-hydroxy group. Under proper storage conditions, chemical stability remains ≥97% for 24 months from the date of manufacture. Always allow the sealed container to reach room temperature before opening to minimize moisture uptake.

Q6: What quantity options are available?
A: Metocin 4-HO-MET 21 MG Pellets are available in five quantity options: 10 pellets, 20 pellets, 30 pellets, 40 pellets, or 50 pellets. This flexibility allows researchers to order appropriate amounts for pilot studies, full-scale experiments, or long-term research programs. Volume discounts apply to larger quantities.

Q7: Can I receive a Certificate of Analysis before placing an order?
A: Absolutely. Contact our scientific support team with the product name (Metocin 4-HO-MET 21 MG Pellets), your institutional affiliation, and intended research application. We will provide a representative CoA from the current or most recent production batch, including HPLC purity percentage, impurity profile, chromatograms, and NMR summary. Full, lot-specific CoAs are included inside every shipment. For bulk or custom orders, we can provide pre-production reference data.

Q8: Are the pellets scored or designed for division?
A: No. The pellets are manufactured as homogeneous, whole-unit analytical standards. They are not scored and are not designed for splitting, cutting, or mechanical division. Crushing, cutting, or otherwise manipulating pellets will compromise dose uniformity and is not recommended for accurate, reproducible research. For studies requiring multiple concentration points, dissolve entire pellets in an appropriate solvent (e.g., DMSO for 10–20 mM stock solutions, ethanol for working dilutions) and perform serial volumetric dilutions using Class A volumetric glassware.

Q9: Who first synthesized 4-HO-MET?
A: 4-HO-MET (Metocin) was first synthesized by the renowned chemist and pharmacologist Alexander Shulgin in the 1960s. Shulgin, known for his extensive work in the field of psychedelic research, noted that the compound has a similar chemical structure to psilocin (4-HO-DMT) but with unique effects and characteristics. His synthesis of 4-HO-MET is considered an important contribution to psychedelic science, expanding our understanding of structure-activity relationships within the tryptamine family.

Q10: What is the difference between 4-HO-MET and psilocin (4-HO-DMT)?
A: The primary difference between 4-HO-MET (Metocin) and psilocin (4-HO-DMT) lies in the substitution on the terminal amine group. Psilocin has two methyl groups (N,N-dimethyl), while 4-HO-MET has one methyl and one ethyl group (N-methyl-N-ethyl). This seemingly small structural change can significantly affect receptor binding affinity, selectivity, metabolic stability, and pharmacological profile. Comparing these two compounds is a common focus of SAR research within the tryptamine class.

Q11: What solvents are recommended for dissolving Metocin 4-HO-MET pellets?
A: 4-HO-MET is freely soluble in DMSO (>40 mg/mL) and ethanol (>30 mg/mL). It is sparingly soluble in water (<0.2 mg/mL) and propylene glycol. For receptor binding assays, prepare a 10 mM stock solution in DMSO, then dilute in assay buffer (final DMSO concentration <0.1% to avoid cell toxicity). For analytical standards, use methanol or acetonitrile. Avoid prolonged exposure to light and heat after dissolution. Solutions in DMSO or ethanol are stable for up to 3 months when stored at -20°C in amber glass vials.

Q12: Can I request a custom dosage or larger quantity?
A: Yes. For research institutions requiring custom dosing formats (e.g., 10mg, 15mg, 30mg pellets) or larger batch quantities (100+ pellets or 500+ pellets), please contact our institutional sales team. We offer custom synthesis and custom pellet compression services with the same high-purity standards and full analytical testing (HPLC, LC-MS, NMR). Minimum order quantities vary by dosage. Contact us for a quotation and to discuss your specific research requirements.

Ready to advance your serotonin receptor and tryptamine pharmacology research? Order Metocin 4-HO-MET 21 MG Pellets today from RChems EU – where purity, precision, and discretion define every shipment.

For bulk institutional inquiries, standing purchase orders, blanket orders, or custom dosing formats, please contact our scientific sales team. Academic discounts and multi-product discounts available for verified institutions.