PRL-8-53

Buy PRL-8-53 Research Chemical Online – USA, Europe and Worldwide

Welcome to RChems EU – your trusted global supplier of premium research chemicals. We are pleased to present PRL-8-53, a high-purity research compound developed originally in the 1970s by Dr. Nikolaus Hansl at Creighton University. PRL-8-53 belongs to the benzoic acid derivative class and has been the subject of limited but noteworthy research into its pharmacological properties. Each batch is synthesized and rigorously tested to exceed 99% purity, ensuring reproducible, publication-ready results for researchers in neuroscience, behavioral pharmacology, and medicinal chemistry. Whether you need to buy PRL-8-53 for memory consolidation studies, receptor binding assays, or structure-activity relationship investigations, RChems EU delivers uncompromised quality with discreet worldwide shipping.

Key Features & Benefits

• >99% Certified Purity – Every batch validated by HPLC, NMR, and mass spectrometry.
• Research-Only Nootropic Reference Standard – Ideal for memory and learning research applications.
• Hydrochloride Salt Form – Enhanced aqueous solubility for in vitro and ex vivo assays.
• Discreet Packaging – Plain, unmarked outer boxes with no chemical names or external identifiers.
• Fast Worldwide Delivery – Expedited shipping to USA, Canada, UK, Australia, and all EU member states.
• Vacuum-Sealed & Tamper-Evident – Protection against moisture, light, and physical damage during transit.
• Batch-Specific COA – Certificate of Analysis with chromatograms included or available upon request.
• Legal Compliance Labeling – Clear “For Research Use Only” marking to support institutional procurement.

Product Specifications

Parameter	Details
Product Name	PRL-8-53 (3-(2-(benzyl(methyl)amino)ethyl)benzoic acid methyl ester hydrochloride)
CAS Number	51352-87-5 (free base) / Not formally assigned for HCl salt
Purity (HPLC)	≥99.0%
Form	Crystalline hydrochloride salt
Molecular Weight (HCl)	319.83 g/mol
Recommended Storage	15–25°C, sealed, away from light, under inert atmosphere recommended
Shipping Stability	30 days at ambient temperature (vacuum-sealed foil with desiccant)

Applications & Usage – For Research Only

PRL-8-53 for research is strictly intended for in vitro and ex vivo laboratory applications, including but not limited to:

• Memory Consolidation Studies – Investigating the compound’s reported effects on acquisition and retention in rodent behavioral models (e.g., passive avoidance, Morris water maze).
• Receptor Binding Assays – Screening for affinity at cholinergic, dopaminergic, serotonergic, and glutamatergic receptor subtypes.
• Neuropharmacology Research – Studying potential modulation of acetylcholine release or monoamine oxidase inhibition.
• Medicinal Chemistry Optimization – Structure-activity relationship (SAR) studies of benzoic acid derivatives.
• Toxicological Profiling – Assessing cytotoxicity in neuronal cell lines (e.g., SH-SY5Y, PC12).
• Analytical Method Development – Validating HPLC-UV or LC-MS/MS methods for novel compound quantification.
• Metabolic Stability Assays – Evaluating hepatic microsomal metabolism and identification of phase I/II metabolites.

Critical Note: This product is not for human or animal consumption, nor for therapeutic, diagnostic, or veterinary use. No in vivo administration is permitted without explicit institutional ethics approval. Published human studies from the 1970s are not a basis for human use today.

Purity & Testing

At RChems EU, analytical rigor defines our quality. Every batch of PRL-8-53 undergoes a comprehensive multi-tiered testing protocol:

1. High-Performance Liquid Chromatography (HPLC-DAD) – Quantifies main compound purity (≥99.0% area normalization) and detects related substances (impurities <1%).
2. Nuclear Magnetic Resonance (¹H NMR & ¹³C NMR) – Confirms structural identity, including the benzylmethylaminoethyl side chain and methyl ester functionality.
3. Mass Spectrometry (LC-MS/MS) – Validates molecular weight (319.83 g/mol for HCl salt) and assesses impurity profiles at ppm levels.
4. Residual Solvent Analysis (GC-FID) – Ensures compliance with ICH Q3C guidelines for Class 2 and Class 3 solvents.
5. Loss on Drying & Residue on Ignition – Confirms absence of excess moisture and inorganic contaminants.
6. Chloride Content Titration – Verifies stoichiometry of the hydrochloride salt (theoretical 11.08% Cl⁻).
7. Heavy Metals Testing (ICP-MS) – Ensures levels below USP <232> thresholds.

A Certificate of Analysis (COA) with raw chromatograms, NMR spectra, and mass spec data is included with every shipment. Only batches meeting 99%+ purity are released. This level of purity directly impacts reproducibility in research – in behavioral pharmacology studies, impurities as low as 1-2% can produce off-target effects that confound results. Our 99%+ guarantee ensures that observed effects are attributable to PRL-8-53 itself.

Safety & Handling Guidelines

WARNING: FOR RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

• Personal Protective Equipment (PPE): Always wear nitrile gloves, chemical safety goggles, and a lab coat when handling powder.
• Ventilation: Handle inside a certified chemical fume hood to prevent inhalation of airborne particulates.
• Spill Management: Gently sweep or vacuum with HEPA filter. Avoid generating dust. Dispose of as hazardous chemical waste per local regulations.
• Storage: Keep original container tightly closed at room temperature (15–25°C), away from strong oxidizers and direct sunlight. Desiccant recommended.
• Incompatibilities: Avoid contact with strong acids, strong bases, and oxidizing agents.
• First Aid (Accidental Exposure): Rinse exposed skin or eyes with copious water for 15 minutes. If inhaled, move to fresh air. If ingested (accidentally), seek immediate medical attention – present the Safety Data Sheet (SDS).

Global Shipping & Discreet Delivery

RChems EU specializes in fast worldwide delivery without compromising your privacy or research security.

• Plain Outer Packaging: Neutral corrugated box or padded envelope – no logos, no “PRL-8-53” text, no chemical names.
• Unmarked Customs Labels: Generic declaration such as “Laboratory Reference Samples – Non-Hazardous” or “Research Materials Only – No Commercial Value.”
• Inner Vacuum-Sealed Foil: Powder is contained in a heat-sealed, opaque, moisture-proof pouch with desiccant.
• Tamper-Evident Seals: Each inner pouch is heat-sealed with a unique batch number visible only upon opening.
• Tracking & Insurance: Every order receives a unique tracking number. Optional shipping insurance covers loss or damage in transit.
• Typical Transit Times (business days):
  • USA & Canada: 5–9 days
  • United Kingdom & Europe: 3–7 days
  • Australia & New Zealand: 7–12 days
  • Rest of world: 10–15 days

No signature required for standard delivery unless requested. Credit card and cryptocurrency statements show a neutral, non-chemical identifier.

Why Choose RChems EU?

• Verified Global Supplier – Thousands of successful research orders shipped to universities, neuroscience labs, and private research institutions since 2017.
• Stealth Packaging Experts – Our discreet delivery protocol maintains a 99.5% customs clearance rate across five continents.
• Real-Time Customer Support – Email or live chat response within 12 hours (including weekends and holidays).
• Bulk & Repeat Order Discounts – Contact us for tiered pricing on quantities of 5g, 10g, 25g, or 50g.
• Flexible Payments – Accepting BTC, ETH, USDT, and major credit cards with privacy protection.
• No Medical Claims – We strictly supply research chemicals; no misleading “human consumption” or “nootropic supplement” language.
• Batch Traceability – Every order is linked to a specific batch with retained samples for one year.

Legal & Safety Disclaimer

By purchasing PRL-8-53 from RChems EU, you acknowledge and agree to the following:

• You are at least 18 years of age (21 in jurisdictions where required for research chemicals).
• The product will be used exclusively for legitimate research purposes in a properly equipped laboratory setting (in vitro or ex vivo only unless licensed for in vivo).
• You have obtained any necessary local, state, and federal licenses required to possess this research chemical.
• You understand that PRL-8-53 is not approved by the FDA, EMA, MHRA, or any other health regulatory agency for any use. It is an unapproved research chemical.
• Compliance with all applicable import, export, and possession laws is solely your responsibility.
• RChems EU reserves the right to cancel any order from jurisdictions where import is explicitly prohibited or where the buyer cannot provide proof of research affiliation upon request.
• No product sold is intended to diagnose, treat, cure, or prevent any disease or condition in humans or animals.

FAQ Section

1. What is PRL-8-53 used for in research?

PRL-8-53 for research is primarily used in behavioral pharmacology and memory consolidation studies. Original research (Hansl & Mead, 1978) reported enhanced learning and memory acquisition in rodent models, though these findings require independent replication. Current research applications include receptor binding assays (cholinergic/dopaminergic systems), cytotoxicity profiling in neuronal cell lines, metabolic stability studies (liver microsomes), and structure-activity relationship investigations of benzoic acid derivatives. No human or veterinary applications are permitted.

2. Is PRL-8-53 legal to buy and import?

PRL-8-53 is not a controlled substance in most countries (USA, UK, EU, Canada, Australia) as of 2025, but this status can change. However, it is an unapproved research chemical – its import, possession, and use are permitted only for legitimate laboratory research. Some countries may regulate it under analogue acts if intended for human consumption (which is strictly prohibited). You are solely responsible for verifying local laws before ordering. RChems EU may request documentation of research status or institutional affiliation.

3. How discreet is your shipping?

Extremely discreet. Your order arrives in a plain, unmarked outer box with no mention of “PRL-8-53,” “nootropic,” “research chemical,” or “RChems EU” on the exterior. The customs declaration reads “Laboratory samples – Non-hazardous” or “Research materials – No commercial value.” Inside, the powder is vacuum-sealed in opaque foil with desiccant to prevent X-ray detection and moisture damage. No external markings suggest pharmaceutical or supplement content.

4. What is the guaranteed purity level, and how is it tested?

All PRL-8-53 batches are independently tested and guaranteed at ≥99.0% purity via HPLC-DAD (area normalization method). Confirmation includes ¹H NMR and ¹³C NMR (structural identity, confirming the benzylmethylaminoethyl side chain and methyl ester), LC-MS/MS (molecular weight 319.83 g/mol for HCl salt), residual solvent analysis (GC-FID), chloride content titration, and heavy metals testing (ICP-MS). A batch-specific Certificate of Analysis (COA) with chromatograms and NMR spectra is included inside the discreet package or available digitally before purchase.

5. What if my package is seized by customs?

While our discreet packaging and compliant documentation keep seizure rates below 1% for most countries, RChems EU cannot guarantee delivery due to varying customs enforcement. If a package is officially seized and you provide a copy of the customs seizure notice, we offer a one-time reshipment at 50% of the order value (or full reshipment if you purchased shipping insurance at checkout – typically 10% of order value). Refunds are not issued for seizures due to legal compliance reasons, as all shipments are properly declared as research samples.

6. How should I store PRL-8-53 powder after opening?

Store in the original, tightly closed container at room temperature (15–25°C) , away from light, moisture, and heat. Due to the methyl ester functionality, hydrolysis is a potential degradation pathway – keep desiccant inside and minimize exposure to humid air. For long-term storage (>6 months), store under inert atmosphere (argon or nitrogen) at 2–8°C. Do not freeze-thaw repeatedly. Once opened, use within 12 months for analytical purposes.

7. What is the significance of the hydrochloride salt form?

PRL-8-53 is supplied as the hydrochloride (HCl) salt, which offers several advantages for research: (1) Enhanced aqueous solubility compared to the free base – the HCl salt dissolves readily in water, phosphate-buffered saline (PBS), and cell culture media. (2) Improved stability – the salt form is less hygroscopic and more resistant to oxidation. (3) Accurate dosing – the crystalline nature allows precise weighing for in vitro assays. When calculating concentrations for receptor binding or cell culture work, use the molecular weight of the HCl salt (319.83 g/mol).

8. Can I order PRL-8-53 in larger quantities?

Yes. For research programs requiring more than the standard quantity, contact RChems EU directly via the website contact form. We offer bulk configurations of 5g, 10g, 25g, and 50g (same 99%+ purity) with volume-based pricing (typically 10–30% discount). Larger orders receive enhanced discreet packaging with additional tamper-evident seals, priority tracking, and expedited handling.

9. What analytical methods are recommended for PRL-8-53 quantification?

For researchers developing analytical methods: typical HPLC conditions include a C18 column (150 mm × 4.6 mm, 5 µm), mobile phase of acetonitrile:0.1% trifluoroacetic acid in water (40:60 v/v), flow rate 1.0 mL/min, UV detection at 254 nm. Retention time for PRL-8-53 is approximately 5.8 minutes under these conditions. For LC-MS/MS, use positive ion mode (ESI+) with MRM transition m/z 284.2 → 91.1 (free base fragment). A validated method summary is included with the COA.

10. Is PRL-8-53 related to other nootropic research compounds?

PRL-8-53 is structurally distinct from racetams (piracetam, aniracetam) or ampakines. It belongs to the benzoic acid derivative class, with a benzylmethylaminoethyl side chain. Some structural similarities exist to certain phenethylamines, but PRL-8-53 lacks the typical phenethylamine core. It was developed through systematic SAR studies at Creighton University in the 1970s and has not been extensively optimized by modern medicinal chemistry. Researchers use it as a unique scaffold for novel memory-enhancing compound development.

Ready to advance your neuroscience research with certified PRL-8-53?
Buy PRL-8-53 from RChems EU today and experience 99% purity, discreet worldwide delivery, and professional support – from a supplier researchers trust worldwide.

This description is for informational purposes only. No claims of safety, efficacy, or legality are made for human or animal use. Always consult your institutional review board, legal counsel, and local laws before purchasing research chemicals.