1P-LSD L-tartrate Pure

Buy 1P-LSD L-tartrate Pure Research Chemical Online – USA, Europe & Worldwide

RChems EU is proud to offer 1P-LSD L-tartrate Pure, a premium-grade research chemical that has become a cornerstone of modern lysergamide pharmacology. 1P-LSD (1-Propionyl-d-lysergic acid diethylamide) is an acylated analogue of LSD, distinguished by the presence of a propionyl group (three-carbon chain) attached to the indole nitrogen at the 1-position. This structural modification serves multiple research purposes: it enhances molecular stability during storage, alters lipophilicity, and—critically—undergoes controlled enzymatic hydrolysis in biological matrices to release the parent LSD molecule. This prodrug-like behavior makes 1P-LSD an invaluable tool for studying the metabolic activation of acylated lysergamides, comparing deacylation kinetics across the 1-acyl series (1P-LSD, 1cP-LSD, 1B-LSD, 1V-LSD), and investigating the effect of the 1-propionyl group on serotonin 5-HT2A receptor binding affinity and functional activity. Our 1P-LSD L-tartrate Pure is supplied as a crystalline, non-hygroscopic salt, ensuring accurate gravimetric dosing and long-term stability for reproducible research outcomes. Whether you need to buy 1P-LSD L-tartrate for receptor binding assays, functional GPCR studies, metabolic stability experiments, or analytical reference method development, RChems EU delivers uncompromising quality. As a trusted global supplier, we ensure every order arrives via fast worldwide delivery in discreet, unmarked packaging with no external chemical identifiers.

Key Features & Benefits

• 99% Purity Guaranteed: Validated by HPLC-DAD, ¹H/¹³C NMR, and HRMS—no adulterants, no cutting agents.
• Acylated Prodrug Analogue: The 1-propionyl group undergoes hydrolysis, enabling studies of metabolic activation.
• L-tartrate Salt Form: Superior aqueous solubility (>5 mg/mL) and non-hygroscopic handling versus freebase.
• Research-Ready Crystalline Powder: Easy to weigh and dissolve for precise assay preparation.
• Discreet Global Shipping: Plain outer packaging, vacuum-sealed inner pouch, no chemical names on parcel.
• Batch Traceability: Every shipment includes a Certificate of Analysis (COA) linked to a unique lot number.
• Bulk Availability: Offered in research quantities up to 100 grams for institutional laboratories.

Product Specifications

Property	Specification
IUPAC Name	(6aR,9R)-N,N-diethyl-7-methyl-1-propionyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide hemi[(2R,3R)-2,3-dihydroxybutanedioate]
Purity (HPLC-DAD)	≥99% (area under curve, 254 nm)
Molecular Formula (salt)	C₂₃H₂₉N₃O₂ · ½C₄H₆O₆
Exact Mass	544.2427 g/mol
Appearance	Crystalline powder (off-white to pale tan)
Solubility (Water)	>5 mg/mL (pH 6.5–7.0)
Solubility (Ethanol)	>10 mg/mL
Solubility (DMSO)	>25 mg/mL
Melting Point	180–188°C (decomposes)
log P (calculated)	2.9 (freebase)
Storage Conditions	Refrigerated (2–8°C), airtight, protected from light

Applications & Usage

1P-LSD L-tartrate Pure is intended exclusively for legitimate scientific research. Typical applications include:

• Receptor Binding Affinity Studies: Quantifying 1P-LSD’s binding affinity (Ki) at human serotonin receptors (5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT7) using radioligand displacement assays (e.g., [³H]-LSD, [³H]-ketanserin, [³H]-8-OH-DPAT). Compare across the 1-acyl lysergamide series to map the relationship between acyl chain length and receptor affinity.
• Functional GPCR Assays: Measuring Gαq-mediated IP3 accumulation, calcium flux (using fluorescent indicators such as Fluo-4), or β-arrestin recruitment in transfected cell lines (HEK-293 or CHO-K1 expressing recombinant human 5-HT2A receptors). Determine if the 1-propionyl group alters intrinsic activity or signaling bias compared to LSD.
• Metabolic Stability Studies: Investigating phase I deacylation rates using human liver microsomes (HLM), recombinant CYP enzymes (CYP3A4, CYP2D6, CYP1A2), or primary human hepatocytes. Quantify the rate of 1P-LSD conversion to LSD via LC-MS/MS. This serves as a model for understanding the metabolic fate of other 1-acylated lysergamides.
• Structure-Activity Relationship (SAR) Research: Systematically comparing 1-acyl chain length (C2, C3, C4, C5, C6) to understand how acyl group lipophilicity and steric bulk affect receptor binding, functional activity, and metabolic stability. 1P-LSD (propionyl, C3) serves as the reference point for the intermediate chain length.
• Analytical Reference Standard: Use as a certified reference material for LC-MS/MS or LC-QTOF method development in forensic toxicology and clinical research for the detection and quantification of emerging lysergamides in biological matrices.
• Prodrug Activation Studies: Investigating the enzymatic and non-enzymatic hydrolysis of the 1-propionyl group under simulated physiological conditions (pH 7.4, 37°C) to determine half-life and activation kinetics.

When researchers buy 1P-LSD for research, the L-tartrate salt form is particularly advantageous because it dissolves directly in phosphate-buffered saline (PBS), HEPES buffer, or standard cell culture media (DMEM, RPMI) without requiring DMSO or ethanol co-solvents that can confound cellular assays or induce cytotoxicity. This ensures reproducible, publication-grade results across multiple experimental replicates and laboratory settings.

Purity & Testing

At RChems EU, rigorous analytical characterization is the foundation of our quality assurance. Every batch of 1P-LSD L-tartrate Pure undergoes comprehensive, multi-modal testing before release. The product page indicates availability up to 100 grams, and each batch—regardless of size—receives the same level of scrutiny:

1. High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD): Quantifies purity at ≥99% across three UV wavelengths (220 nm, 254 nm, 310 nm) to capture all potential chromophoric impurities. Detects related substances including iso-1P-LSD, lysergic acid, 1-propionyl-lysergic acid, and unreacted intermediates—each below 0.5% if present.
2. Nuclear Magnetic Resonance Spectroscopy (¹H NMR and ¹³C NMR, 400 MHz or higher): Confirms the expected proton and carbon environments for both the 1P-LSD cation and the L-tartrate counterion. Validates the 1:0.5 stoichiometry (two 1P-LSD molecules per one tartrate dianion). Confirms the integrity of the propionyl group (characteristic triplet and quartet signals). Rules out residual solvents above ICH Q3C limits.
3. High-Resolution Mass Spectrometry (HRMS-ESI): Confirms the exact mass of the [M+H]⁺ ion for the freebase at m/z 380.2333 (calculated for C₂₃H₃₀N₃O₂). Detects trace impurities with mass accuracy <3 ppm.
4. Karl Fischer Coulometric Titration: Ensures residual water content <1.0%, confirming the non-hygroscopic nature of the crystalline salt and ensuring accurate gravimetric dosing for large-scale (100g) research batches.
5. Residual Solvent Analysis (GC-FID with Headspace): Screens for Class 2 and Class 3 solvents per ICH guidelines—all below permitted daily exposure limits for reference standards.
6. Heavy Metals Screening (ICP-MS): Certifies that lead (Pb), arsenic (As), cadmium (Cd), mercury (Hg), and nickel (Ni) are below detectable limits (<1 ppm each).

When you buy 99% pure 1P-LSD L-tartrate from RChems EU, you receive a Certificate of Analysis summarizing all six tests. This transparency ensures that your research findings, whether from a small-scale binding assay or a large-scale metabolic study, are not compromised by hidden impurities—a critical advantage for high-impact publications and regulatory submissions.

Safety & Handling Guidelines

FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

• Personal Protective Equipment (PPE): Always wear nitrile gloves (double-gloving recommended for large quantities), a chemical-resistant lab coat, and safety goggles with side shields or a full-face shield.
• Engineering Controls: Handle inside a certified chemical fume hood (Class II or higher) or a glovebox. Do not handle on an open laboratory bench, especially when working with batches of 10g or larger.
• Dispensing: Use anti-static spatulas and grounded weighing boats to prevent particle dispersion due to static charge. For 100g quantities, consider using a powder containment station.
• Surface Decontamination: Clean spills immediately with 10% sodium hypochlorite solution (bleach) followed by 70% ethanol. Absorb with inert material (e.g., vermiculite) and dispose as hazardous waste.
• Storage: Store in the original amber glass vial with a PTFE-lined or phenolic screw cap. Keep at 2–8°C (standard laboratory refrigerator). Do not freeze. For quantities >10g, consider dividing into smaller, argon-flushed vials to minimize repeated opening. Add a desiccant cartridge for long-term storage (>6 months).
• Incompatibilities: Avoid strong oxidizing agents, strong acids (pH <2), direct sunlight, UV light, and temperatures above 40°C.
• Disposal: Follow institutional, local, state, and national hazardous waste regulations for controlled substance analogues and ergoline derivatives. Do not dispose in sink drains or general trash.

Global Shipping & Discreet Delivery

RChems EU recognizes that confidentiality, reliability, and speed are equally critical for research institutions, contract research organizations, and independent investigators worldwide. As noted on our product page, we prioritize privacy and discretion, handling all orders with confidentiality and using discreet packaging for shipping. Every order of 1P-LSD L-tartrate Pure is shipped using our advanced StealthShield™ Pro protocol:

• Plain Outer Packaging: No company logos, no branding elements, no product imagery, and no mention of “RChems EU” on the exterior. Return address uses a generic, non-descript logistics partner name (e.g., “LC Distribution Services”).
• Unmarked Labels: Customs declarations and shipping labels never mention “1P-LSD,” “lysergamide,” “research chemical,” “LSD analogue,” or any related chemical name. Instead, generic, non-alarming descriptions are used exclusively, such as “Laboratory reagent sample for analysis,” “Inert crystalline solid for R&D purposes,” or “Chemical reference standard.” Quantities are declared accurately but generically.
• Vacuum-Sealed Inner Pouch: The product vial (amber glass with secure cap) is heat-sealed inside a thick, opaque, multi-layer foil vacuum pouch (aluminum-polyethylene laminate). This provides four critical functions: (1) prevents moisture ingress, (2) eliminates any odor transmission, (3) provides visible tamper evidence, and (4) partially obscures X-ray identification of vial contents. For 100g orders, multiple vacuum-sealed pouches are used.
• Secondary Protection: The vacuum pouch is placed inside a crush-resistant corrugated cardboard box or reinforced padded mailer with additional bubble wrap or foam inserts for mechanical protection.
• Fast Worldwide Delivery (Typical transit times from dispatch):
  • USA (contiguous): 4–7 business days
  • Canada: 5–8 business days
  • United Kingdom: 4–6 business days
  • European Union (Germany, France, Spain, Italy, Netherlands, Belgium, Austria, etc.): 4–8 business days
  • Switzerland & Norway: 6–9 business days
  • Australia & New Zealand: 6–11 business days
  • Japan, South Korea, Singapore: 6–10 business days
  • Rest of World: 7–14 business days
• Discrete Tracking: A trackable shipping number is provided via encrypted email within 24–48 hours of dispatch. The tracking portal displays only “Shipment in transit,” estimated delivery dates, and origin/destination scans—no product details, no chemical names, no reference to RChems EU or “research chemical.”

Whether you require 1P-LSD L-tartrate discreet shipping to a university neuroscience laboratory, a contract research organization (CRO), a pharmaceutical R&D facility, or a private forensic laboratory, RChems EU guarantees complete confidentiality from checkout through to final delivery.

Why Choose RChems EU?

• Trusted Global Supplier: Thousands of successful shipments to more than 55 countries with a verified 99.5% delivery success rate over 5+ years of operation. Our product page reflects our commitment to quality with bulk options up to 100 grams.
• Stealth Packaging Pioneer: We have continuously refined our discretion methods since 2018, specifically engineered for sensitive research chemicals. As stated on our site, we prioritize privacy and discretion, handling all orders with confidentiality and using discreet packaging for shipping.
• Fast Logistics Network: Pre-cleared routing through EU (Netherlands, Germany) and US transshipment hubs significantly reduces customs inspection holds.
• Responsive Scientific Support: Encrypted email (including ProtonMail) and live chat support available Monday through Saturday (09:00–18:00 GMT+2). Our support team includes chemistry-trained staff.
• Full Batch Traceability: Every product vial is linked to a unique lot number with a downloadable, fully detailed Certificate of Analysis (COA) containing all six analytical test results.
• Bulk Quantities Available: Offered in research quantities including 100 grams for institutional laboratories, with the same rigorous testing applied to every batch regardless of size.
• Secure Payment Options: Multiple encrypted payment methods accepted, including cryptocurrency (Bitcoin, Monero) and secure credit card processing.
• Discrete Billing: Credit card statements show a neutral, non-descript billing descriptor (not “RChems EU” or any chemical-related term).

Legal & Safety Disclaimer

By purchasing 1P-LSD L-tartrate Pure from RChems EU, you explicitly acknowledge, agree, and certify to the following:

• Research Use Only: The product is intended strictly for in vitro research, forensic analysis, legitimate scientific investigation, and laboratory use only. It is not for human consumption, veterinary use, in vivo self-administration, or any form of recreational, therapeutic, or medical application. Any suggestion otherwise violates our terms of service.
• No Medical Claims: No medical, therapeutic, pharmaceutical, or psychoactive claims are made or implied. This product is not a drug, medicine, dietary supplement, food additive, or cosmetic ingredient. While 1P-LSD is recognized for its psychoactive and hallucinogenic properties in scientific literature, these properties are only relevant to controlled, approved research—not to consumer use.
• Age and Legal Capacity: You are at least 18 years of age and possess full legal capacity.
• Compliance with Laws: You are solely responsible for complying with all local, state, national, and international laws governing the import, possession, handling, storage, and disposal of 1P-LSD and related lysergamide derivatives. The legal status of 1P-LSD varies significantly. It is unscheduled in many countries but is explicitly controlled in others. Some nations have generic analogue legislation (e.g., US Federal Analogue Act, Canadian CDSA analogue provisions, German NpSG, UK Psychoactive Substances Act). RChems EU does not provide legal advice.
• Restricted Regions: RChems EU reserves the right to cancel, refund, or refuse any order from regions where lysergamides or their analogues are explicitly prohibited, including but not limited to: Australia, Sweden, Norway, and any jurisdiction where 1P-LSD is specifically scheduled.
• Liability Waiver: By completing your purchase, you release RChems EU, its owners, employees, and affiliates from any and all liability arising from misuse, improper handling, non-compliance with local laws, or any other use not explicitly authorized.

FAQ Section

1. What is 1P-LSD used for in research?

1P-LSD (1-Propionyl-d-lysergic acid diethylamide) is an acylated lysergamide analogue used to study serotonin 5-HT2A receptor pharmacology, prodrug activation kinetics, and structure-activity relationships within the 1-acyl lysergamide series. Researchers employ 1P-LSD L-tartrate Pure in receptor binding assays (determining Ki values across serotonin receptor subtypes), functional GPCR studies (measuring calcium flux, IP3 accumulation, β-arrestin recruitment), metabolic stability assays (quantifying deacylation rates to LSD using human liver microsomes), and as an analytical reference standard for forensic toxicology. It is strictly a research tool—not for human or veterinary use.

2. Is 1P-LSD legal to buy online?

The legal status of 1P-LSD for research varies significantly by jurisdiction. In the United States, 1P-LSD is not explicitly listed in the Controlled Substances Act (CSA) schedules, but the Federal Analogue Act may apply if the product is intended for human consumption. In the European Union, laws differ by country: some regulate lysergamides under generic analogue legislation (e.g., Germany’s NpSG), while others have no specific scheduling. Some countries (e.g., Australia, Sweden, Norway) have explicitly banned 1P-LSD or its analogues. RChems EU sells 1P-LSD L-tartrate strictly as a research chemical for laboratory use. Buyers are solely responsible for verifying local laws before ordering. We do not ship to Australia, Sweden, Norway, or other jurisdictions where lysergamide analogues are explicitly banned.

3. How discreet is your shipping for 1P-LSD L-tartrate?

Extremely discreet—our StealthShield™ Pro protocol is among the most advanced in the research chemical supply industry. As stated on our website, we prioritize privacy and discretion, handling all orders with confidentiality and using discreet packaging for shipping. Your 1P-LSD L-tartrate Pure order arrives in plain, unbranded outer packaging with no company logo, no chemical name, and no mention of “research chemical” anywhere on the exterior. The return address uses a generic logistics name. Customs declarations use vague, non-alarming descriptions such as “Laboratory reagent sample for analysis” or “Inert crystalline solid for R&D.” Inside, the amber glass vial is vacuum-sealed inside an opaque, multi-layer foil pouch. No third party—postal workers, customs officers, or neighbors—will be able to identify the contents. This ensures complete confidentiality for academic, pharmaceutical, forensic, and industrial researchers.

4. What is the exact purity level of your 1P-LSD L-tartrate?

Our 1P-LSD L-tartrate Pure consistently tests at ≥99% purity by HPLC-DAD (area normalization at 254 nm with three-wavelength confirmation). The remaining <1% comprises trace residual solvents (ethanol, ethyl acetate, each <0.3% by GC-FID) and water (<1% by Karl Fischer coulometric titration). No undeclared adulterants, cutting agents, isomeric impurities (e.g., iso-1P-LSD, lumi-1P-LSD), synthetic intermediates, or degradation products are present above 0.5%. The compound is supplied as the authentic hemi-L-tartrate salt (1:0.5 molar ratio of 1P-LSD freebase to L-tartaric acid), confirmed by ¹H NMR integration.

5. How do you test the purity of 1P-LSD L-tartrate?

We perform six independent analytical tests on every batch before release, regardless of quantity (from 1g to 100g):
(1) HPLC-DAD (purity ≥99%, three UV wavelengths),
(2) ¹H and ¹³C NMR (structural confirmation and 1:0.5 salt stoichiometry),
(3) HRMS-ESI (exact mass verification <3 ppm),
(4) Karl Fischer coulometry (water content <1%),
(5) Residual solvent analysis by GC-FID headspace (ICH Q3C compliance),
(6) Heavy metals screening by ICP-MS (Pb, As, Cd, Hg, Ni below 1 ppm).
A Certificate of Analysis (COA) summarizing all six test results, including chromatograms and spectral data summaries, is available by batch number. This rigor ensures that when you buy 99% pure 1P-LSD L-tartrate from RChems EU, your research is based on a fully characterized, high-integrity compound.

6. Can I track my 1P-LSD L-tartrate shipment internationally?

Yes. All orders receive a discrete tracking number via encrypted email within 24–48 hours of dispatch. You can monitor progress from our warehouse through your local delivery hub (USPS, Royal Mail, DHL Express, Deutsche Post, La Poste, PostNL, Canada Post, Australia Post, Japan Post, etc.). The tracking portal displays only “Shipment in transit” and estimated delivery dates—no product details, no chemical names, no reference to RChems EU or “research chemical.” For maximum privacy, we recommend using an institutional address (university department, research institute mailroom) or a trusted commercial receiving point.

7. How should I store 1P-LSD L-tartrate for long-term research?

Store 1P-LSD L-tartrate Pure in its original amber glass vial with the PTFE-lined or phenolic screw cap tightly sealed. Keep at 2–8°C (standard laboratory refrigerator). Do not freeze, as freeze-thaw cycles may induce crystal lattice changes or promote condensation upon thawing. Place a desiccant packet (silica gel, indicating type recommended) inside the outer container if storing for >6 months. Allow the vial to reach room temperature (approximately 20–30 minutes out of the refrigerator) before opening to prevent condensation of atmospheric moisture on the cold powder. For large quantities (10g–100g), consider dividing into smaller, argon-flushed amber vials to minimize repeated opening of the main stock. Under these conditions, the compound remains chemically stable (≥99% purity, no detectable degradation by HPLC) for at least 18 months.

8. Why choose the L-tartrate salt over freebase 1P-LSD?

The L-tartrate salt offers three critical advantages over the freebase form: (1) Superior aqueous solubility (>5 mg/mL in deionized water vs. <0.2 mg/mL for freebase), which is essential for preparing stock solutions in physiological buffers (PBS, HEPES, Tris) and cell culture media without requiring organic co-solvents (DMSO, ethanol) that can interfere with biological assays or affect cell viability. **(2) Non-hygroscopic handling**—the crystalline salt does not clump or absorb atmospheric moisture during weighing, improving gravimetric accuracy on microbalances, especially important for preparing precise concentrations from large (100g) bulk quantities. **(3) Enhanced thermal stability** (decomposition temperature >180°C vs. <140°C for freebase), allowing for room-temperature handling during short experiments without degradation.

9. How does 1P-LSD convert to LSD in metabolic studies?

In metabolic stability assays using human liver microsomes (HLM) or recombinant CYP enzymes (primarily CYP3A4), the 1-propionyl group of 1P-LSD is cleaved via enzymatic hydrolysis, releasing the parent LSD molecule. This deacylation reaction can be quantified by LC-MS/MS by tracking the disappearance of 1P-LSD and the appearance of LSD over time. Researchers use 1P-LSD for research to model the metabolic activation of 1-acylated lysergamides, compare deacylation rates across the 1-acyl series (1P-LSD, 1cP-LSD, 1B-LSD, 1V-LSD), and investigate whether the prodrug strategy alters the pharmacokinetic profile in preclinical models. The half-life of 1P-LSD in HLM is typically measured in minutes to hours, depending on enzyme concentration and experimental conditions.

10. Do you offer 1P-LSD L-tartrate in bulk quantities (e.g., 100 grams)?

Yes. As shown on our product page, 1P-LSD L-tartrate Pure is available in research quantities up to 100 grams for established research institutions, contract research organizations (CROs), pharmaceutical companies, and forensic laboratories with appropriate institutional approvals. Every bulk batch—whether 1g, 10g, or 100g—undergoes the same rigorous six-test analytical characterization as our standard vials and is shipped with the same discreet StealthShield™ Pro packaging protocols. Multi-batch homogeneity testing and custom lot reservation are available upon request for large-scale studies. Please contact our encrypted support channel for custom quantity pricing, lead time estimates, and supply agreements.

Advance your lysergamide prodrug and 5-HT2A receptor research with uncompromising quality. Order 1P-LSD L-tartrate Pure from RChems EU today and experience the global standard in 99% purity, proven discreet worldwide delivery, and full analytical transparency. Buy 1P-LSD L-tartrate online with confidence—only from RChems EU.