F-DCK HCl (2-fluorodeschloroketamine)

Buy F-DCK HCl Research Chemical Online – USA, Europe & Worldwide

The arylcyclohexylamine class of research chemicals has garnered significant attention in neuropharmacology due to the distinctive NMDA receptor antagonist properties of compounds such as ketamine and its analogs. F-DCK HCl (2-fluorodeschloroketamine hydrochloride) represents a structural modification of the ketamine scaffold, featuring two key changes: the replacement of the 2-chloro group on the phenyl ring with a fluorine atom, and the absence of the 2-oxo group present in ketamine. These structural alterations significantly impact the compound’s receptor binding affinity, metabolic stability, and overall pharmacokinetic profile.

Fluorine substitution is of particular interest in medicinal chemistry due to the unique electronic and steric properties of the fluorine atom, which can enhance metabolic stability, alter lipophilicity, and modulate receptor interactions. For researchers investigating the molecular mechanisms of NMDA receptor antagonists and the structure-activity relationships of arylcyclohexylamines, F-DCK HCl offers a distinct chemical probe to explore how halogen substitution (chlorine vs. fluorine) and the presence or absence of the 2-oxo group affect receptor binding, selectivity, and functional activity. When you buy F-DCK HCl from RChems EU, you acquire a high-purity research compound manufactured under strict quality controls. Our 99% pure F-DCK HCl is intended exclusively for laboratory research—not for human or animal consumption—enabling precise, reproducible experiments in receptor pharmacology, neurochemistry, and behavioral neuroscience.

Key Features & Benefits

• Verified 99%+ Purity: Every batch undergoes independent HPLC, LC-MS, and ¹H/¹³C NMR analysis to guarantee ≥99% purity.
• Arylcyclohexylamine Derivative: Structural analog of ketamine for comparative NMDA receptor antagonist research.
• 2-Fluoro Substitution: The fluorine atom replaces the 2-chloro group of ketamine, enabling SAR studies on halogen effects (F vs. Cl) on receptor binding and metabolic stability.
• Deschloro Modification: The absence of the 2-oxo group distinguishes F-DCK from ketamine, providing insights into the role of the cyclohexanone moiety.
• Hydrochloride Salt Form: Enhanced aqueous solubility and crystalline stability for precise solution preparation in assay buffers.
• Potent NMDA Receptor Antagonist: Acts as a non-competitive antagonist at the NMDA receptor’s PCP binding site, blocking glutamatergic neurotransmission in research models.
• Distinct Pharmacokinetic Profile: Fluorine substitution may enhance metabolic stability compared to chloro analogs.
• Worldwide Delivery: Fast, tracked shipping to the USA, Canada, Europe, Australia, and select Asian research hubs.
• Discreet Packaging Protocol: Plain outer boxes, unmarked labels, vacuum-sealed inner bags—no chemical names on the parcel.

Product Specifications

Applications & Usage

⚠️ Strictly for laboratory research use only. Not for human or animal consumption.

F-DCK HCl is utilized in a range of non-clinical, pre-clinical, and basic science research applications. Typical areas of investigation include:

• NMDA Receptor Binding Assays: Evaluating affinity (Ki) for the phencyclidine (PCP) binding site within the NMDA receptor ion channel using radioligand displacement (e.g., [³H]MK-801 or [³H]TCP) in rat brain homogenates or transfected cell lines expressing recombinant NMDA receptor subunits.
• Ion Channel Functional Studies: Measuring NMDA receptor-mediated calcium influx or electrophysiological recordings (patch-clamp) to assess the potency and efficacy of channel blockade.
• Structure-Activity Relationship (SAR) Investigations: Systematically comparing F-DCK HCl with ketamine (2-chloro, with 2-oxo), deschloroketamine (no halogen, with 2-oxo), and 2-F-2-oxo-PCM (2-fluoro with 2-oxo) to map the impact of:
  • Halogen substitution (F vs. Cl) on the phenyl ring
  • Presence or absence of the 2-oxo group on the cyclohexane ring
    on NMDA receptor affinity, selectivity, and use-dependent block kinetics.
• Glutamatergic Neurotransmission Research: Investigating the role of NMDA receptors in synaptic plasticity, long-term potentiation (LTP), and excitotoxicity using in vitro brain slice preparations or neuronal cell cultures.
• Metabolic Stability Research: Evaluating phase I metabolism using hepatic microsomes or S9 fractions with LC-MS/MS quantification, particularly studying N-demethylation, hydroxylation, and the impact of fluorine substitution on metabolic stability (fluorine can block oxidative metabolism at adjacent sites).
• Analytical Reference Standard: Serving as a high-purity calibrant for forensic toxicology, wastewater analysis, or novel psychoactive substance (NPS) screening methods.
• In Vitro Neurotoxicity Screening: Assessing cytotoxicity, mitochondrial function, and oxidative stress markers in neuronal cell cultures (e.g., cortical neurons, SH-SY5Y cells).

Researchers are encouraged to consult peer-reviewed literature (e.g., Journal of Pharmacology and Experimental Therapeutics, Neuropharmacology, European Journal of Pharmacology, ACS Chemical Neuroscience) for established in vitro protocols. RChems EU does not provide research protocols but guarantees the compound’s structural integrity and purity for such applications.

Purity & Testing

Reproducibility in NMDA receptor pharmacology and neuropharmacology research depends critically on compound purity. Impurities—particularly other arylcyclohexylamine isomers, synthetic intermediates, or degradation products—can produce false-positive signals in receptor binding assays or confound functional readouts. That is why 99% pure F-DCK HCl from RChems EU is subjected to a multi-laboratory quality control workflow:

1. High-Performance Liquid Chromatography (HPLC-DAD): Quantitative analysis at multiple wavelengths. Minimum acceptance criterion: ≥99.0% peak area purity.
2. Liquid Chromatography-Mass Spectrometry (LC-MS): Confirms molecular ion [M+H]⁺ = 222.1 for the freebase and detects trace-level organic impurities down to 0.05%.
3. Nuclear Magnetic Resonance (NMR): Both proton (¹H) and carbon-13 (¹³C) NMR verify the correct cyclohexanone ring system, N-methyl group, and 2-fluoro substitution pattern on the phenyl ring (characteristic aromatic fluorine coupling patterns). The hydrochloride salt is confirmed by the absence of freebase amine signals. Any spectral deviation—particularly signals indicative of incorrect substitution or the presence of the 2-oxo isomer—triggers batch rejection.
4. Residual Solvent Analysis (GC-MS): Ensures compliance with ICH limits for Class 2 and Class 3 solvents.
5. Heavy Metal Testing (ICP-MS): Confirms levels below 20 ppm for lead, arsenic, cadmium, and mercury.

Each batch is assigned a unique lot number, and a Certificate of Analysis (COA) is available upon request. This rigorous testing ensures that when you buy F-DCK HCl for research, you receive a compound that performs consistently from order to order.

Safety & Handling Guidelines

⚠️ FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

• Personal Protective Equipment (PPE): Always wear nitrile gloves, a lab coat, and chemical splash goggles when handling F-DCK HCl powder.
• Engineering Controls: Use a certified chemical fume hood or glove box to prevent inhalation of airborne particulates.
• First Aid Measures:
  • Inhalation: Remove to fresh air. If breathing difficulty persists, seek medical attention.
  • Skin Contact: Wash with soap and copious water for 15 minutes. Remove contaminated clothing.
  • Eye Contact: Rinse cautiously with water for 15 minutes. Consult an ophthalmologist if irritation persists.
  • Ingestion: Do NOT induce vomiting. Rinse mouth and seek immediate medical attention.
• Spill Management: Vacuum or sweep gently (avoid generating dust). Collect in a sealed, labeled container for hazardous waste disposal.
• Storage: Store in a tightly sealed, amber glass vial at room temperature (20–25°C) in a desiccator, protected from light and moisture.

By purchasing from RChems EU, you confirm that you are a qualified researcher (or authorized agent) and that your facility can handle this compound safely.

Global Shipping & Discreet Delivery

RChems EU has perfected a discreet, reliable global logistics system for all research chemical orders, including F-DCK HCl. We understand that confidentiality is essential for many academic and private research organizations.

What discreet delivery means for you:

• Plain Outer Packaging: Your order arrives in a non-descript padded envelope or small cardboard box. No logos, no brand names, no chemical identifiers.
• Unmarked Shipping Label: The return address uses a generic name (e.g., “L.C. Distribution” or “WH Logistics”). No reference to “RChems EU” or “F-DCK HCl.”
• Vacuum-Sealed Inner Bags: Each bag is heat-sealed to prevent leakage, odor, and tampering. No chemical name appears on the inner bag.
• No External Documentation: Invoices, COAs, or packing slips are sent via encrypted email only—never placed inside the parcel.

Fast worldwide delivery times (tracked):

Every shipment includes a real-time tracking number. Expedited courier options (FedEx Priority, DHL Express) are available at checkout for faster delivery (2–5 days globally).

Why Choose RChems EU?

• Stealth Packaging Experts: Over 7,000 successful shipments to 45+ countries with minimal customs interference.
• Third-Party Verified Purity: Every batch is independently tested. We do not sell unverified or “research grade” material without documentation.
• Responsive Scientific Support: Technical inquiries answered within 24 hours. Replacement policy for lost or damaged shipments (terms apply).
• No Minimum Order Quantity (MOQ): Order 1 gram or 1000 grams—same meticulous packaging and quality standards.
• Flexible Payment Methods: Secure cryptocurrency (BTC, ETH, USDT) and select credit card options.
• Global Compliance Awareness: We monitor international regulations and adjust shipping policies accordingly.

Legal & Safety Disclaimer

⚠️ IMPORTANT – READ CAREFULLY BEFORE PURCHASING

F-DCK HCl (2-fluorodeschloroketamine hydrochloride) is sold by RChems EU strictly as a research chemical and is not for human consumption, animal testing, or any form of in vivo use without appropriate institutional ethical approval. This product is not a pharmaceutical, medicinal product, dietary supplement, or recreational substance.

Legal Status Varies by Jurisdiction: F-DCK HCl may be a controlled substance or regulated analog in certain countries, states, or territories. In the United States, ketamine is a Schedule III controlled substance, and structural analogs may be considered controlled substance analogues under the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Several European countries have specific analogue legislation or blanket scheduling for arylcyclohexylamines. It is your sole responsibility to verify the legal status of F-DCK HCl in your country, state, or province before ordering.

By completing your purchase, you certify that:

1. You are at least 18 years of age.
2. You are a qualified researcher affiliated with a bona fide laboratory or academic institution.
3. You will use this product exclusively for lawful, laboratory-based research purposes.
4. You will not introduce this compound into the body of any human or animal.

RChems EU reserves the right to cancel any order that appears destined for non-research use or for a jurisdiction where F-DCK HCl is prohibited.

FAQ Section

1. What is F-DCK HCl used for in research?

F-DCK HCl (2-fluorodeschloroketamine hydrochloride) is used in neuropharmacological research to study NMDA receptor antagonism, the phencyclidine (PCP) binding site within the NMDA receptor ion channel, and structure-activity relationships among arylcyclohexylamine derivatives. It is particularly valuable for SAR studies comparing halogen substitution (fluorine vs. chlorine) and the presence or absence of the 2-oxo group in ketamine analogs. Typical applications include radioligand binding assays, ion channel functional studies (electrophysiology, calcium influx), and metabolic stability research.

2. Is F-DCK HCl legal to buy and possess for research?

Legality depends on your jurisdiction. F-DCK HCl is not explicitly scheduled at the US federal level but may be considered a controlled substance analogue under the Federal Analogue Act (21 U.S.C. § 813) if intended for human consumption. Many European countries have analogue legislation or specific scheduling for arylcyclohexylamines. You must check your local regulations before ordering. RChems EU ships on the condition that you assume full legal responsibility.

3. How discreet is the shipping from RChems EU?

Extremely discreet. All F-DCK HCl orders are shipped in plain, unmarked packaging with no external branding. The shipping label uses a generic return address. Inner bags are vacuum-sealed with no chemical names or CAS numbers visible. Our stealth protocol has enabled successful deliveries to over 45 countries with a 99%+ success rate.

4. What is the guaranteed purity level of your F-DCK HCl?

Every batch of F-DCK HCl from RChems EU is independently tested to be ≥99% pure via HPLC-DAD, with confirmation by LC-MS and ¹H/¹³C NMR. A lot-specific Certificate of Analysis (COA) is available for every order upon request.

5. How is the 99% purity tested?

We employ a five-tier analytical protocol:

• HPLC-DAD for quantitative purity (≥99% peak area at multiple wavelengths).
• LC-MS for molecular weight confirmation ([M+H]⁺ = 222.1 for freebase) and trace impurity detection down to 0.05%.
• ¹H and ¹³C NMR for structural confirmation (cyclohexanone ring, N-methyl group, 2-fluoro substitution pattern on the phenyl ring with characteristic fluorine coupling).
• GC-MS for residual solvent analysis (ICH compliance).
• Heavy metal testing (ICP-MS) to confirm levels below 20 ppm.

All testing is performed by an ISO 17025-accredited contract laboratory.

6. Can you ship F-DCK HCl to my country (USA, UK, Germany, Australia, Canada)?

RChems EU ships F-DCK HCl worldwide, including the USA, Canada, United Kingdom, Germany, France, Italy, Spain, Netherlands, Switzerland, Norway, Australia, and New Zealand. However, due to varying legal statuses of arylcyclohexylamines, we strongly recommend contacting our support team before ordering if you are located in Germany, Sweden, Finland, or any country with broad analogue legislation. For countries with strict import controls (e.g., Japan, Singapore, South Korea), we do not currently ship F-DCK HCl.

7. How should I store F-DCK HCl after delivery?

Store F-DCK HCl in a tightly sealed, amber glass vial at room temperature (20–25°C) in a desiccator, protected from light and moisture. For long-term storage (>6 months), refrigeration at 4°C under inert atmosphere (argon or nitrogen) is recommended. Always allow the sealed container to reach room temperature before opening to prevent condensation. The hydrochloride salt form offers enhanced stability compared to the freebase.

8. What is the difference between F-DCK HCl and ketamine?

The key structural differences are:

• Ketamine has a 2-chloro group and a 2-oxo group (cyclohexanone ring)
• F-DCK HCl has a 2-fluoro group and no 2-oxo group (the cyclohexane ring lacks the ketone)

Additionally, F-DCK lacks the 2-oxo group present in ketamine. In NMDA receptor research, these modifications affect:

• Halogen substitution (F vs. Cl) alters electronic properties and metabolic stability (fluorine can block oxidative metabolism)
• The absence of the 2-oxo group changes the overall ring conformation and receptor binding kinetics
• Lipophilicity and blood-brain barrier permeability

Comparing these compounds allows researchers to map the impact of halogen substitution and the presence/absence of the 2-oxo group on arylcyclohexylamine pharmacology.

9. What is the difference between F-DCK HCl and DCK (deschloroketamine)?

The difference lies in the phenyl ring substituent:

• DCK (deschloroketamine) has no halogen on the phenyl ring (hydrogen at the 2-position)
• F-DCK HCl has a fluorine atom at the 2-position

Both compounds lack the 2-oxo group found in ketamine (i.e., both have a cyclohexane ring rather than cyclohexanone). Comparing these two compounds allows researchers to investigate the impact of adding a fluorine atom (vs. hydrogen) at the 2-position of the phenyl ring on NMDA receptor binding, selectivity, functional activity, and metabolic stability, while keeping the cyclohexane ring (no 2-oxo) constant.

10. What is the difference between F-DCK HCl and 2-F-2-oxo-PCM?

The difference lies in the presence of the 2-oxo group:

• F-DCK HCl has a cyclohexane ring (no 2-oxo group)
• 2-F-2-oxo-PCM has a cyclohexanone ring (with 2-oxo group)

Both share the same 2-fluorophenyl substitution. Comparing these two compounds allows researchers to investigate the impact of the 2-oxo group on NMDA receptor binding, selectivity, and functional activity while keeping the 2-fluoro substitution constant. This comparison helps elucidate the role of the cyclohexanone moiety in ketamine-like pharmacology.

11. Do you offer a reshipment policy if customs seizes my package?

Yes. RChems EU offers a one-time reshipment policy for confirmed customs seizures in most countries, provided that the original shipping address is valid and the buyer did not violate known local laws. Crypto payments qualify for the full reshipment guarantee. Terms and conditions apply—please contact customer support for details.

12. Can I get a Certificate of Analysis (COA) before ordering?

Absolutely. Contact our support team via email with the product name (F-DCK HCl or 2-fluorodeschloroketamine hydrochloride) and your research affiliation. We will provide a redacted or full COA for the current batch, including HPLC chromatograms and NMR spectra (with characteristic fluorine coupling patterns), subject to verification of legitimate research intent.

Ready to advance your NMDA receptor and fluorinated arylcyclohexylamine research? Order high-purity F-DCK HCl from RChems EU today and experience unmatched product quality, stealth global delivery, and professional scientific support. Buy F-DCK HCl for Research

RChems EU – Your trusted global supplier of 99% pure research chemicals.